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Gorham-Stout disease

Disease definition

Gorham-Stout disease (GSD) is a rare disease of massive osteolysis associated with proliferation and dilation of lymphatic vessels. GSD may affect any bone in the body and can be monostotic or polyostotic. Symptoms at presentation are dependent upon the location(s) of the disease; the most common symptom is localized pain. The disease may be discovered after a pathological fracture.


Classification level: Disorder
  • Synonym(s):
    • Gorham disease
    • Gorham syndrome
    • Idiopathic massive osteolysis
    • Progressive massive osteolysis
    • Vanishing bone disease
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: M89.5
  • OMIM: 123880
  • UMLS: C0029438
  • MeSH: -
  • GARD: 6542
  • MedDRA: 10071283

Detailed information


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