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Loeffler endocarditis

Disease definition

A rare restrictive cardiomyopathy characterized by hypereosinophilia and fibrous thickening of the endocardium, with usually large thrombi against the ventricle walls, that can lead to cardiovascular complications such as heart failure and thromboembolism. It manifests with symptoms like edema, fatigue and shortness of breath. It is usually secondary to eosinophil-associated tissue damage and is associated with idiopathic hypereosinophilic syndrome, chronic eosinophilic leukemia, carcinoma, or lymphoma.

ORPHA:75566

Classification level: Disorder
  • Synonym(s):
    • Eosinophilic endocarditis
  • Prevalence: Unknown
  • Inheritance: -
  • Age of onset: Adolescent, Childhood, Adult
  • ICD-10: I42.3
  • ICD-11: BC43.20
  • OMIM: -
  • UMLS: C0206143
  • MeSH: -
  • GARD: -
  • MedDRA: 10052841

  A summary on this disease is available in Deutsch (2014) Español (2014) Français (2014) Italiano (2014) Nederlands (2014) Polski (2014, pdf) Russian (2014, pdf) Polski ()

Additional information

Further information on this disease

Patient-centred resources for this disease

Research activities on this disease

Specialised Social Services

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.