Orphanet: Polyarteritis nodosa

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Polyarteritis nodosa

Disease definition

Polyarteritis nodosa (PAN) is a rare, clinically heterogeneous, rheumatologic disease characterized by necrotizing inflammatory lesions affecting small- and medium-sized blood vessels. PAN most commonly affects skin, joints, peripheral nerves, the gut, and the kidney.


Classification level: Disorder
  • Synonym(s):
    • Küssmaul-Maier disease
    • PAN
    • Periarteritis nodosa
  • Prevalence: 1-9 / 100 000
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: M30.0
  • OMIM: -
  • UMLS: C0031036
  • MeSH: D010488
  • GARD: 7360  7414
  • MedDRA: 10036024
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