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Boutonneuse fever

Disease definition

A rare spotted fever rickettsiosis caused by infection with the tick-borne bacterium Rickettsia conorii, characterized by the onset of fever after an incubation period of about a week, followed by a centripetally spreading maculopapular rash, which may evolve into a petechial form. Accompanying symptoms are headaches, myalgia and/or arthralgia, among others. The typical ''tache noire'' may be observed at the site of the tick bite for several days. The disease is endemic in Africa, Southern Europe, and India.


Classification level: Disorder
  • Synonym(s):
    • Mediterranean spotted fever
  • Prevalence: 1-5 / 10 000
  • Inheritance: Not applicable 
  • Age of onset: All ages
  • ICD-10: A77.1
  • ICD-11: 1C31.1
  • OMIM: -
  • UMLS: C0006060
  • MeSH: D001907
  • GARD: -
  • MedDRA: 10006045
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