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AA amyloidosis

Disease definition

A rare amyloidosis that complicates chronic inflammatory disorders and is characterized by the aggregation and deposition of amyloid fibrils composed of serum amyloid A protein, an acute phase reactant. The kidney is involved in virtually all patients and dominates the clinical picture. Other frequently involved sites are the liver, the spleen, suprarenal gland, gut and less frequently the heart.


Classification level: Disorder
  • Synonym(s):
    • Inflammatory amyloidosis
    • Reactive amyloidosis
    • Secondary amyloidosis
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: Childhood, Adolescent, Adult
  • ICD-10: E85.3
  • ICD-11: 5D00.1
  • OMIM: -
  • UMLS: C3536715
  • MeSH: C000718787
  • GARD: 10560
  • MedDRA: 10039811

Detailed information

General public


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