Orphanet: Wild type ABeta2M amyloidosis

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Wild type ABeta2M amyloidosis

Disease definition

A form of amyloidosis affecting patients with chronic kidney disease (CKD), on long term dialysis characterized by the accumulation of amyloid fibrils consisting of beta 2 microglobulin (β2M) deposits in the musculoskeletal system leading to carpal tunnel syndrome (CTS), chronic arthropathy, cystic bone lesions, destructive osteoarthropathy, and pathologic fractures.


Classification level: Disorder
  • Synonym(s):
    • ABeta2Mwt amyloidosis
    • Dialysis-related amyloidosis
    • Dialysis-related arthropathy
    • Wild type ABeta2-microglobulinic amyloidosis
  • Prevalence: 1-9 / 100 000
  • Inheritance: Not applicable 
  • Age of onset: Adult
  • ICD-10: E85.3
  • ICD-11: 5D00.3
  • OMIM: -
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information

General public

ERN : produced/endorsed by ERN(s)
FSMR : produced/endorsed by FSMR(s)
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