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Mal de Meleda

Disease definition

Mal de Meleda (MdM) is a diffuse palmoplantar keratoderma, initially reported in the Island of Meleda, characterized by symmetric palmoplantar hyperkeratosis that progressively extends to the dorsal surfaces of hands and feet (transgrediens). The disease can be associated to hyperhidrosis, lichenoid plaques and perioral erythema.

ORPHA:87503

Classification level: Disorder
  • Synonym(s):
    • Keratosis palmoplantaris transgrediens of Siemens
    • Meleda disease
    • Transgrediens palmoplantar keratoderma of Siemens
  • Prevalence: 1-9 / 100 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Neonatal, Infancy, Childhood
  • ICD-10: Q82.8
  • OMIM: 248300
  • UMLS: C0025221
  • MeSH: -
  • GARD: 92
  • MedDRA: -

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The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.