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Acute liver failure

Disease definition

A rare hepatic disease characterized by acute onset of severe liver dysfunction without evidence of underlying chronic liver disease. Patients present with nonspecific symptoms like jaundice, upper right abdominal pain, nausea, vomiting, pruritus, fatigue, and fever. The condition may rapidly progress to hepatic encephalopathy, coagulopathy, and life-threatening multiorgan failure. Liver biopsy typically shows massive hepatic necrosis.

ORPHA:90062

Classification level: Disorder
  • Synonym(s):
    • Acute hepatic failure
    • Fulminant hepatic failure
  • Prevalence: 1-5 / 10 000
  • Inheritance: Not applicable 
  • Age of onset: Infancy, Childhood, Adolescent, Adult, Elderly
  • ICD-10: K72.0
  • OMIM: -
  • UMLS: C0162557
  • MeSH: D017114
  • GARD: -
  • MedDRA: 10000804

  A summary on this disease is available in Español (2020) Français (2020) Nederlands (2020)

Detailed information

Guidelines

ERN produced/endorsed by ERN(s)   FSMR produced/endorsed by FSMR(s)

Additional information

Further information on this disease

Patient-centred resources for this disease

Research activities on this disease

Specialised Social Services

The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.