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Charcot-Marie-Tooth disease type 1E

Disease definition

A rare subtype of CMT1 characterized by a variable clinical presentation. Onset within the first two years of life with a delay in walking is not uncommon; however, onset may occur later. CMT1E is caused by point mutations in the PMP22 (17p12) gene. The disease severity depends on the particular PMP22 mutation, with some cases being very mild and even resembling hereditary neuropathy with liability to pressure palsies, while others having an earlier onset with a more severe phenotype (reminiscent of Dejerine-Sottas syndrome) than that seen in CMT1A, caused by gene duplication. These severe cases may also report deafness and much slower motor nerve conduction velocities compared to CMT1A patients.


Classification level: Disorder
  • Synonym(s):
    • CMT1E
    • Charcot-Marie-Tooth disease-deafness syndrome
    • Charcot-Marie-Tooth disease-hearing loss syndrome
  • Prevalence: Unknown
  • Inheritance: Autosomal dominant 
  • Age of onset: Childhood, Infancy
  • ICD-10: G60.0
  • ICD-11: 8C20.0
  • OMIM: 118300
  • UMLS: C2931686
  • MeSH: C537986  C538078
  • GARD: 9190
  • MedDRA: -

Detailed information

General public


Disease review articles

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FSMR : produced/endorsed by FSMR(s)
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