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Non-acquired panhypopituitarism

Disease definition

A rare genetic pituitary disease characterized by variable deficiency of all hormones produced in the anterior lobe of the pituitary gland. Clinical manifestations include hypothyroidism, hypogonadism, growth retardation and short stature, and secondary adrenal insufficiency. Age of onset is variable. Signs and symptoms usually develop gradually, and loss of the different hormones is often sequential.


Classification level: Disorder
  • Synonym(s):
    • Genetic panhypopituitarism
  • Prevalence: -
  • Inheritance: X-linked recessive or Autosomal recessive 
  • Age of onset: All ages
  • ICD-10: E23.0
  • ICD-11: 5A61.0
  • OMIM: 262600  312000
  • UMLS: C5680191
  • MeSH: -
  • GARD: -
  • MedDRA: 10033662

Detailed information


Genetic Testing

ERN produced/endorsed by ERN(s)   FSMR produced/endorsed by FSMR(s)
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