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TSH-secreting pituitary adenoma
Disease definition
A rare, functioning, pituitary adenoma characterized by the presence of a pituitary mass associated with high levels of circulating, free, thyroid hormones in conjunction with normal to high levels of TSH and unresponsiveness of TSH levels to TRH stimulation and T3 suppression tests, typically manifesting with signs and symptoms of mild to moderate hyperthyroidism (e.g. goiter (most frequently observed), palpitation, excessive sweating, arrhythmia, weight loss, tremor) and/or tumor mass effect (such as headache, visual field defects, hypopituitarism). Occasionally, cosecretion of prolactin and/or growth hormone may cause galactorrhea and/or acromegaly.
ORPHA:91347
Classification level: Disorder- Synonym(s):
- Pituitary thyrotrophic adenoma
- TSH-oma
- Thyroid stimulating hormone-secreting pituitary adenoma
- Thyrotroph adenoma
- Prevalence: -
- Inheritance: -
- Age of onset: Childhood, Adolescent, Adult, Elderly
- ICD-10: D35.2
- ICD-11: 2F37.Y
- OMIM: -
- UMLS: C0346303
- MeSH: -
- GARD: -
- MedDRA: -
A summary on this disease is available in Deutsch (2019) Español (2019) Français (2019) Italiano (2019) Nederlands (2019)
Detailed information
Guidelines
- Clinical practice guidelines
- English (2018) - Eur J Endocrinol
Disease review articles
- Clinical genetics review
- English (2020) - GeneReviews
produced/endorsed by ERN(s) 
produced/endorsed by FSMR(s)Additional information
Further information on this disease
Patient-centred resources for this disease
Research activities on this disease
Specialised Social Services
The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.