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Dense deposit disease

Disease definition

A histological subtype of C3 glomerulopathy characterized by C3 deposition in renal tissue in the absence or near-absence of immunoglobulin deposits, in a patient with the classic clinical features of glomerulonephritis and electron microscopic findings of highly electron-dense intra-membranous, osmiophilic deposits.

ORPHA:93571

Classification level: Subtype of disorder
  • Synonym(s):
    • Membranoproliferative glomerulonephritis type 2
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Childhood
  • ICD-10: N03.6
  • OMIM: 609814
  • UMLS: C0268743
  • MeSH: D015432
  • GARD: 8555
  • MedDRA: -

Detailed information

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