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Disease definition

GRFoma is a type of pancreatic endocrine tumor (see this term) that hypersecretes growth hormone-releasing factor (GRF or GHRH) and that clinically resembles a pituitary adenoma (see this term) as patients present with acromegaly. In addition to the pancreas, this tumor can also occur in the lungs or small intestine, are usually large > 6cm and approximately 1/3 have metastasized at the time of diagnosis. It often co-occurs with Zollinger-Ellison syndrome or multiple endocrine neoplasia type 1 (MEN 1; see these terms).


Classification level: Disorder
  • Synonym(s):
    • GRF tumor
    • Growth hormone releasing factor tumor
  • Prevalence: Unknown
  • Inheritance: Not applicable 
  • Age of onset: Adult
  • ICD-10: C25.9
  • ICD-11: 2C10.1
  • OMIM: -
  • UMLS: C5680245
  • MeSH: -
  • GARD: -
  • MedDRA: -

Detailed information


Disease review articles

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