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Familial partial lipodystrophy

Disease definition

Familial partial lipodystrophy (FPLD) is a group of rare genetic lipodystrophic syndromes characterized, in most cases, by fat loss from the limbs and buttocks, from childhood or early adulthood, and often associated with acanthosis nigricans, insulin resistance, diabetes, hypertriglyceridemia and liver steatosis.


Classification level: Group of disorders
  • Synonym(s):
    • FPLD
  • Prevalence: 1-9 / 100 000
  • Inheritance: Autosomal dominant or Autosomal recessive 
  • Age of onset: -
  • ICD-10: E88.1
  • OMIM: -
  • UMLS: C0271694
  • MeSH: D052496
  • GARD: 11962
  • MedDRA: -

Detailed information


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