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Spastic paraplegia type 7

Disease definition

A form of hereditary spastic ataxia characterized by an onset usually in adulthood (but ranging from 10-72 years) of progressive bilateral lower limb weakness and spasticity and sometimes predominant cerebellar ataxia. In addition to frequent sphincter dysfunction and decreased vibratory sense at the ankles, manifestations may include optical neuropathy, nystagmus, blepharoptosis, ophthalmoplegia, decreased hearing, scoliosis, pes cavus, motor and sensory neuropathy, muscle atrophy, parkinsonism, and dystonia.


Classification level: Disorder
  • Synonym(s):
    • SPG7
  • Prevalence: Unknown
  • Inheritance: Autosomal recessive 
  • Age of onset: Childhood, Adolescent, Adult, Elderly
  • ICD-10: G11.4
  • OMIM: 607259
  • UMLS: C1846564  C3711370
  • MeSH: -
  • GARD: 4927
  • MedDRA: -

Detailed information

Article for general public


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