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Recruiting trial = Recruiting trial
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National clinical trial(s)

BELGIUM

VLAAMS BRABANT
LEUVEN

FRANCE

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR

FRANCE

CENTRE-VAL DE LOIRE
TOURS

Recruiting trial
Ongoing trial
Evaluation of Metabolomic Analysis in Early Diagnosis of ALS (Phase IV) - FR
CHRU de Tours - Hôpital Trousseau
Laboratoire de Biochimie - Trousseau

FRANCE

ILE-DE-FRANCE
GARCHES

Ongoing trial
Long-Term Effect of LIAM (Lung Insufflation Assist Maneuver) on Respiratory Performance in Non-invasive Ventilated Patients Suffering From Neuromuscular Disease - FR
CHU Paris IdF Ouest - Hôpital Raymond Poincaré
Centre d'Investigation Clinique et Technologique 805 - CIC-IT de Garches

FRANCE

ILE-DE-FRANCE
GARCHES

Ongoing trial
Protocole de Validation Clinique du Logiciel d'Interface Cerveau-Ordinateur RoBIK Pour la Communication Des Patients Atteints de Maladie Neuromusculaires (MNM) - FR
CHU Paris IdF Ouest - Hôpital Raymond Poincaré
Centre d'Investigation Clinique et Technologique 805 - CIC-IT de Garches

FRANCE

ILE-DE-FRANCE
GARCHES

Ongoing trial
Establishment of a Non-invasive and Indirect Measure of Volitional Pimax (PI MAX STIM) - FR
CHU Paris IdF Ouest - Hôpital Raymond Poincaré
Service de Physiologie-Explorations Fonctionnelles

FRANCE

ILE-DE-FRANCE
PARIS

FRANCE

ILE-DE-FRANCE
PARIS

An Open-Label Safety Extension Study of TRO19622 in Amyotrophic Lateral Sclerosis (ALS) patients treated with riluzole - FR
CHU Paris-GH La Pitié Salpêtrière-Charles Foix - Hôpital Pitié-Salpêtrière
Département de Neurologie - Pôle des Maladies du Système Nerveux

FRANCE

ILE-DE-FRANCE
PARIS

Recruiting trial
Ongoing trial
DOSERALS : Study of Dopamine and Serotonin Transporters in Patients With Amyotrophic Lateral Sclerosis and Controls. Analysis With 123I-FP-CIT (Datscan) and 123 I-ADAM Brain SPECT (Phase III) - FR
CHU Paris-GH La Pitié Salpêtrière-Charles Foix - Hôpital Pitié-Salpêtrière
Groupement hospitalier universitaire Pitié-Salpétrière

FRANCE

ILE-DE-FRANCE
PARIS

RespiStimALS : Can Diaphragm Pacing Delay Non Invasive Ventilation in Amyotrophic Lateral Sclerosis ? a Randomized Controlled Study
CHU Paris-GH La Pitié Salpêtrière-Charles Foix - Hôpital Pitié-Salpêtrière
Service de Pneumologie et Réanimation médicale

FRANCE

ILE-DE-FRANCE
PARIS

LISLA: A Phase II Open Multicenter Study of Lithium in Patients With Amyotrophic Lateral Sclerosis
CHU Paris-GH St-Louis Lariboisière F.Widal - Hôpital Saint-Louis
Délégation à la Recherche Clinique et à l'Innovation de l'AP-HP

FRANCE

NOUVELLE AQUITAINE
LIMOGES

FRANCE

OCCITANIE
MONTPELLIER

Ongoing trial
MD1003-ALS : Effect of MD1003 in Amyotrophic Lateral Sclerosis: a Randomized Double Blind Placebo Controlled Pilot Study (Phase II)
CHU de Montpellier - Hôpital Gui de Chauliac
Clinique du Motoneurone et Pathologies neuromusculaires

FRANCE

OCCITANIE
MONTPELLIER

IMODALS : Immuno-modulation in Amyotrophic Lateral Sclerosis - a Phase II Study of Safety and Activity of Low Dose Interleukin-2
CHU de Montpellier - Hôpital Gui de Chauliac
Clinique du Motoneurone et Pathologies neuromusculaires

FRANCE

OCCITANIE
MONTPELLIER

Ongoing trial
Funded by an IRDiRC memberROCK-ALS: Inhibition of Rho Kinase (ROCK) with Fasudil as disease-modifying treatment for ALS - FR
CHU de Montpellier - Hôpital Gui de Chauliac
Clinique du Motoneurone et Pathologies neuromusculaires

FRANCE

OCCITANIE
MONTPELLIER

Recruiting trial
Ongoing trial
Influence of the Vitamin D Blood Levels on the Amyotrophic Lateral Sclerosis Phenotype - FR
CHU de Montpellier - Hôpital Gui de Chauliac
Unité Scléroses en plaques et substances blanches

GERMANY

Baden-Württemberg
ULM

Phase II Study of pioglitazone in patients with amyotrophic lateral sclerosis - DE
Universitäts- und Rehabilitationskliniken Ulm (RKU)
Klinik für Neurologie

GERMANY

Baden-Württemberg
ULM

Recruiting trial
Ongoing trial
Pharyngeal Electrical Stimulation in Amyotrophic Lateral Sclerosis: A Pilot Study With 20 Patients (Phase I/II) DE
Universitäts- und Rehabilitationskliniken Ulm (RKU)
Klinik für Neurologie

GERMANY

Bayern
MÜNCHEN

Recruiting trial
Ongoing trial
Funded by an IRDiRC memberROCK-ALS: Inhibition of Rho Kinase (ROCK) With Fasudil as Disease-modifying Treatment for ALS -DE-
Klinikum rechts der Isar der Technischen Universität München
Neurologische Klinik und Poliklinik

IRELAND

County Dublin
DUBLIN

Recruiting trial
Ongoing trial
Funded by an IRDiRC memberTUDCA-ALS: Safety and Efficacy of TUDCA as add-on Treatment in Patients Affected by ALS - IE
Trinity College Dublin
Research Motor Neurone - Trinity Biomedical Sciences Institute

ITALY

EMILIA ROMAGNA
MODENA

Rapamycin (Sirolimus) treatment for amyotrophic lateral sclerosis - RAP-ALS
Nuovo Ospedale Civile S. Agostino Estense di Modena
Centro SLA - Dipartimento di Neuroscienze

ITALY

LOMBARDIA
MILANO

ErythroPOietin in ALS: a Study of dose-finding and Safety
Fondazione IRCCS Istituto Neurologico "Carlo Besta"
U.O. Neurologia III

ITALY

LOMBARDIA
MILANO

PROMISE: Protein misfolding, Amyotrophic lateral sclerosis and Guanabenz: a phase II RCT with futility design
Fondazione IRCCS Istituto Neurologico "Carlo Besta"
U.O. Neurologia III

NETHERLANDS

Utrecht
UTRECHT

Trial of Sodium Valproate in Amyotrophic Lateral Sclerosis
UMC Utrecht - Universitair Medisch Centrum Utrecht
Polikliniek Neuromusculaire Ziekten

NETHERLANDS

Utrecht
UTRECHT

A randomised sequential trial of Lithium in amyotrophic lateral sclerosis
UMC Utrecht - Universitair Medisch Centrum Utrecht
Polikliniek Neuromusculaire Ziekten

PORTUGAL

SUL
LISBOA

Memantine for Disability in Amyotrophic Lateral Sclerosis (Phase II-III) - Terminated -
Hospital de Sta. Maria - Centro Hospitalar de Lisboa Norte, EPE.
Faculdade de Medicina de Lisboa

SPAIN

Comunidad Valenciana
SANT JOAN D'ALACANT

Phase I/II Clinical Trial on the Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis - ES (completed)
Instituto de Neurociencias de Alicante (CSIC-UMH)
Unidad de Neurobiología del Desarrollo

SPAIN

Comunidad Valenciana
SANT JOAN D'ALACANT

Extension CMN/ELA: Phase I/II Clinical Trial on the Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis (completed)
Instituto de Neurociencias de Alicante (CSIC-UMH)
Unidad de Neurobiología del Desarrollo

SPAIN

Madrid
MADRID

Memantine (Ebixa) for functional disability in amyotrophic lateral sclerosis (Phase IV) - ES (terminated)
Hospital Universitario 12 de Octubre
Unidad multidisciplinar de enfermedades neuromusculares y ELA

SPAIN

Murcia
EL PALMAR, MURCIA

Phase I/II Clinical Trial on the Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis - ES (completed)
Hospital Clínico Universitario Virgen de la Arrixaca
Unidad de trasplante hematopoyético y terapia celular

SPAIN

Murcia
EL PALMAR, MURCIA

Extension CMN/ELA: Phase I/II Clinical Trial on the Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis (completed)
Hospital Clínico Universitario Virgen de la Arrixaca
Unidad de trasplante hematopoyético y terapia celular

SWITZERLAND

Suisse Alémanique
ST. GALLEN

UNITED STATES

Kansas
KANSAS CITY

Recruiting trial
Ongoing trial
Funded by an IRDiRC memberPhase 2 Study of Rasagiline for Treatment of Amyotrophic Lateral Sclerosis - US
University of Kansas Medical Center Research Institute

FRANCE

ILE-DE-FRANCE
PARIS

DENMARK

Hovedstaden
COPENHAGEN

GERMANY

Baden-Württemberg
FREIBURG

Ongoing trial
Can treatment with human growth hormone increase strength in spinal muscular atrophy type II and III (phase II study)?
Zentrum für Kinder- und Jugendmedizin Freiburg
Klinik für Neuropädiatrie und Muskelerkrankungen

GERMANY

Baden-Württemberg
FREIBURG

GERMANY

Baden-Württemberg
FREIBURG

Ongoing trial
An Open Label Multi-part First-in-human Study of Oral LMI070 in Infants With Type 1 Spinal Muscular Atrophy (Phase I/II) - DE
Zentrum für Kinder- und Jugendmedizin Freiburg
Klinik für Neuropädiatrie und Muskelerkrankungen

GERMANY

Nordrhein-Westfalen
ESSEN

Ongoing trial
An Open Label Multi-part First-in-human Study of Oral LMI070 in Infants With Type 1 Spinal Muscular Atrophy (Phase I/II) - DE
Universitätsklinikum Essen
Klinik für Kinderheilkunde I - Bereich Neuropädiatrie und SPZ

ITALY

LAZIO
ROMA

Phase II, multicenter, randomized, adaptive, double-blind, placebo controlled study to assess safety and efficacy of olesoxime (TRO19622) in 3-25 year old Spinal Muscular Atrophy (SMA) patients - IT
IRCCS Ospedale Pediatrico Bambino Gesù - SEDE SAN PAOLO
Unità di Malattie Neuromuscolari e Neurodegenerative - Laboratorio di Medicina Molecolare

ITALY

LOMBARDIA
MILANO

Recruiting trial
Ongoing trial
Long Term Safety Study of Amifampridine Phosphate in Ambulatory Patients With Spinal Muscular Atrophy (SMA) Type 3
Fondazione IRCCS Istituto Neurologico "Carlo Besta"
U.O. Neurologia IV - Malattie Neuromuscolari e Neuroimmunologia

SPAIN

Cataluña
ESPLUGUES DE LLOBREGAT

ITALY

VENETO
PADOVA

A pilot trial with clenbuterol in spinal and bulbar muscular atrophy (SBMA)
Azienda Ospedaliera di Padova
Clinica Neurologica

Multinational clinical trial(s)

GERMANY

Bayern
MÜNCHEN

Ongoing trial
Funded by an IRDiRC memberROCK-ALS: Inhibition of Rho Kinase (ROCK) with Fasudil as disease-modifying treatment for ALS
Klinikum rechts der Isar der Technischen Universität München
Neurologische Klinik und Poliklinik