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Ensayo(s) clínico(s) nacional(es)

Baden-Württemberg
FREIBURG

DECLINE (CAMN107ADE18T): Imatinib 400 mg daily versus Nilotinib 300 mg twice daily in patients with chronic myeloid leukemia (CML) in 1st chronic phase and confirmed major molecular response (MMR) receiving Imatinib at a dose of 400 mg daily. An open-label, randomized multicenter phase 3b study to determine the conversion rate from MMR to molecular response >= 4 log (MR4) after two years - DE
Universitätsklinikum Freiburg
Klinik für Innere Medizin I - Hämatologie, Onkologie und Stammzelltransplantation

Baden-Württemberg
MANNHEIM
Phase II study to evaluate Glivec (imatinib mesylate) to induce progression arrest in aggressive Fibromatosis / desmoid tumors not amenable to surgical resection with R0 intent or accompanied by unacceptable function loss - DE - Completed
Universitätsmedizin Mannheim
Sarkom-Zentrum

Berlin
ADDRESS: NOT PROVIDED - DE
An open-label extension study to CQTI571A2102 to evaluate the long-term safety, tolerability and efficacy of QTI571 (imatinib) in the treatment of severe pulmonary arterial hypertension -DE-
Institution: Information not provided - DE

Berlin
ADDRESS: NOT PROVIDED - DE

International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL) Testing Imatinib in Combination With Two Different Cytotoxic Chemotherapy Backbones -DE-
Institution: Information not provided - DE

Niedersachsen
HANNOVER
A randomized, open label, multicenter phase III study to evaluate the efficacy and safety of Nilotinib versus Imatinib in adult patients with unresectable or metastatic Gastrointestinal Stromal Tumors (GIST)
Medizinische Hochschule Hannover
Klinik für Hämatologie, Hämostaseologie, Onkologie und Stammzelltransplantation

Nordrhein-Westfalen
AACHEN
CHOICES: A randomised Phase II trial of Imatinib (IM) versus Hydroxychloroquine (HCQ) and IM for patients with Chronic Myeloid Leukaemia (CML) in Major Cytogenetic Response (MCyR) with residual disease detectable by quantitative polymerase chain reaction (Q-PCR) - DE
Universitätsklinikum Aachen
Klinik für Onkologie, Hämatologie und Stammzelltransplantation (Med. Klinik IV)

Thüringen
JENA
CML Imatinib Versus Nilotinib: A Phase III multicenter, open-label, randomized rtudy of Imatinib versus Nilotinib in adult patients with newly diagnosed Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in chronic phase - DE
Universitätsklinikum Jena
Klinik für Innere Medizin II - Abteilung Hämatologie und Internistische Onkologie

Thüringen
JENA
An open label phase II study of the combination of Imatinib and Lonafarnib in patients with CML in chronic phase and absence of good molecular remission - DE
Universitätsklinikum Jena
Klinik für Innere Medizin II - Abteilung Hämatologie und Internistische Onkologie

Thüringen
JENA
A phase IV, open-label, multicenter study of Dasatinib in chronic-phase Chronic Myeloid Leukemia patients with chronic, low-grade non-hematologic toxicity to Imanitib - DE Completed
Universitätsklinikum Jena
Klinik für Innere Medizin II - Abteilung Hämatologie und Internistische Onkologie

OBERÖSTERREICH
LINZ
A "window of opportunity" trial with Brentuximab Vedotin and Imatinib in patients with relapsed or refractory ALK+ anaplastic large cell lymphoma or patients ineligible for chemotherapy (phase I-II)-AT
Kepler Universitätsklinikum - Med Campus III.
Universitätsklinik für Hämatologie und Internistische Onkologie

SALZBURG
SALZBURG
A "window of opportunity" trial with Brentuximab Vedotin and Imatinib in patients with relapsed or refractory ALK+ anaplastic large cell lymphoma or patients ineligible for chemotherapy (phase I-II)-AT
Universitätsklinikum der Paracelsus Medizinischen Privatuniversität
Universitätsklinik für Innere Medizin III

TIROL
INNSBRUCK
A "window of opportunity" trial with Brentuximab Vedotin and Imatinib in patients with relapsed or refractory ALK+ anaplastic large cell lymphoma or patients ineligible for chemotherapy (phase I-II)-AT
Medizinische Universität Innsbruck
Universitätsklinik für Innere Medizin V - Hämatologie und Onkologie

WIEN
ADDRESS: NOT PROVIDED - AT
IMPRES Extension: An Extension to QTI571A2301 to Evaluate the Long-term Safety, Tolerability and Efficacy of Oral QTI571 (Imatinib) in the Treatment of Severe Pulmonary Arterial Hypertension (Phase 3) - AT
Institution: Information not provided - AT

WIEN
ADDRESS: NOT PROVIDED - AT

International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL) Testing Imatinib in Combination With Two Different Cytotoxic Chemotherapy Backbones - AT
Institution: Information not provided - AT

WIEN
WIEN
A "window of opportunity" trial with Brentuximab Vedotin and Imatinib in patients with relapsed or refractory ALK+ anaplastic large cell lymphoma or patients ineligible for chemotherapy (phase I-II)-AT
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Hämatologie und Hämostaseologie

WIEN
WIEN
DASCERN: An open label, randomized (2:1) Phase 2b study of Dasatinib vs. Imatinib in patients with Chronic Phase Chronic Myeloid Leukemia who have not achieved an optimal response to 3 months of therapy with 400 mg Imatinib - AT
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Hämatologie und Hämostaseologie

WIEN
WIEN
ENESTg1: A Randomized, Open Label, Multi-center Phase III Study to Evaluate the Efficacy and Safety of Nilotinib Versus Imatinib in Adult Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors (GIST) - AT
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Onkologie

WIEN
WIEN

Three Versus Five Years of Adjuvant Imatinib as Treatment of Patients With Operable GIST With a High Risk for Recurrence: A Randomised Phase III Study - AT
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Onkologie

NAMUR
YVOIR
ENESTnd: A Phase III Multi-center, Open-label, Randomized Study of Imatinib Versus Nilotinib in Adult Patients With Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Chronic Myelogenous Leukemia in Chronic Phase (CML-CP) - BE
Cliniques Universitaires UCL de Mont-Godinne
Department of Hematology

VLAAMS BRABANT
LEUVEN
IMPRES Extension: An extension study to QTI571A2301 to evaluate the longterm safety, tolerability and efficacy of oral QTI571 (imatinib) in the treatment of severe pulmonary arterial hypertension - BE
UZ Leuven - Campus Gasthuisberg
Centrum pulmonale hypertensie/ Pulmonary hypertension center

Aragón
ZARAGOZA
Validación del análisis por PCR digital durante la interrupción programada del tratamiento con imatinib en pacientes con leucemia mieloide crónica PCR negativos (Fase IV) (completado)
Hospital Universitario Miguel Servet
Servicio de Hematología y Hemoterapia

Aragón
ZARAGOZA
ENESTnd: Estudio fase III, multicéntrico, abierto, aleatorizado de imatinib frente a nilotinib, en pacientes adultos con leucemia mieloide crónica cromosoma Filadelfia positivo (Ph+) en fase crónica (LMC-FC) de nuevo diagnóstico (completado)
Hospital Universitario Miguel Servet
Servicio de Hematología y Hemoterapia

Castilla - La Mancha
TOLEDO
Tratamiento con inhibidores de tirosina quinasas en pacientes con variantes de mastocitosis sistémica de mal pronóstico: ensayo clínico para sujetos sin mutación D816V de KIT y búsqueda de inhibidores de KIT D816V+ (Fase III) (completado)
Hospital Virgen del Valle
Instituto de Estudios de Mastocitosis de Castilla La Mancha

Cataluña
BADALONA

Quimioterapia e Imatinib, seguido de trasplante de progenitores hematopoyéticos en adultos jóvenes (edad inferior a 55 años) con leucemia aguda linfoblástica PH (BCR-ABL) positiva
ICO Badalona - Hospital Germans Trias i Pujol
Servicio de Hematología Clínica

Cataluña
BADALONA

Estudio fase III randomizado en el que se compara el tratamiento con imatinib adyuvante durante 3 años frente a 5 años para pacientes con GIST operable con alto riesgo de recurrencia
ICO Badalona - Hospital Germans Trias i Pujol
Servicio de Oncología Médica

Cataluña
BARCELONA

SeliGIST: Ensayo fase Ib/II multicéntrico de Selinexor en combinación con Imatinib en pacientes con tumores del estroma gastrointestinal (GISTs) metastáticos y/o irresecables
Hospital Universitari Vall d'Hebron
Servicio de Oncología Médica

Cataluña
SABADELL
Estudio en Fase III, aleatorio, abierto, multicéntrico, para evaluar la eficacia y seguridad de Nilotinib respecto a Imatinib en pacientes adultos con tumores estromales gastrointestinales (GIST) no resecables o metastásicos (completado)
Corporación Sanitaria Parc Taulí. Hospital de Sabadell
Servicio de Oncología

Comunidad Valenciana
VALENCIA
Tumores estromales gastrointestinales (GIST) que expresan el receptor KIT, de riesgo intermedio o alto localizados, completamente resecados. Ensayo controlado aleatorio con Imatinib mesilato (Glivec) como adyuvante respecto a ningún tratamiento adicional después de una cirugía completa (Fase III) (finalizado)
Fundación Instituto Valenciano de Oncología (IVO)
Servicio de Oncología Médica

Madrid
ADDRESS: NOT PROVIDED - ES
ENESTcmr: Estudio abierto, aleatorio, de Nilotinib respecto a Imatinib estándar (400/600 mg QD) comparando la cinética de la respuesta molecular completa para pacientes con leucemia mieloide crónica en fase crónica (CML-CP) con evidencia de leucemia persistente por RQ-PCR (Fase III) (completado)
Institution: Information not provided - ES

Madrid
ADDRESS: NOT PROVIDED - ES
Dasatinib en sujetos con leucemia mielogénica crónica o leucemia linfoblástica aguda con cromosoma Filadelfia positivo que han experimentado beneficios clínicos en los actuales protocolos START o CA180-039: análisis a largo término de seguridad y eficacia (Fase II) (completado)
Institution: Information not provided - ES

Madrid
ADDRESS: NOT PROVIDED - ES
Estudio de extensión del estudio en fase III, multicéntrico, abierto, aleatorio, de Imatinib respecto a Nilotinib en pacientes adultos con leucemia mielode crónica cromosoma Filadelfia positivo (Ph+) en fase crónica (LMC-FC) (completado)
Institution: Information not provided - ES

Madrid
ADDRESS: NOT PROVIDED - ES
Estudio multicéntrico en Fase Ib, de brazo único, de búsqueda de dosis, de Imatinib en combinación con el inhibidor de la de la fosfatidilinositol 3-quinasa (PI3K) BKM120 en pacientes con tumores estromales gastrointestinales (GIST) que fracasaron en la terapia previa con Imatinib y Sunitinib (completado)
Institution: Information not provided - ES

Madrid
ADDRESS: NOT PROVIDED - ES
Protocolo multicéntrico, abierto para proporcionar QTI571 a pacientes con HAP que hayan participado en uno de los estudios de extensión y que el investigador considere que se beneficiarán de la continuación del tratamiento con QTI571 (Fase III) (finalizado)
Institution: Information not provided - ES

Madrid
ADDRESS: NOT PROVIDED - ES

Ensayo internacional de fase 3 en leucemia linfoblástica aguda positiva para cromosoma Filadelfia (LLA Ph+) de evaluación del imatinib en combinación con dos diferentes esquemas de quimioterapia citotóxica - ES
Institution: Information not provided - ES

Madrid
MADRID
IMPRES: Ensayo clínico de 24 semanas, aleatorio, controlado por placebo, doble ciego, multicéntrico, evaluando la eficacia y seguridad del QTI571 oral como terapia adicional en el tratamiento de la hipertensión arterial pulmonar severa: Imatinib en la hipertensión arterial pulmonar, un estudio de eficacia aleatorio (Fase III) (completado)
Hospital Universitario 12 de Octubre
Unidad Multidisciplinar de Hipertensión Pulmonar

Madrid
MADRID
IMPRES Extension: Extension del estudio QTI571A2301 para evaluar a largo plazo la seguridad, tolerabilidad y eficacia de QTI571 oral (Imatinib) en el tratamiento de la hipertensión arterial pulmonar severa (Fase III) (completado)
Hospital Universitario 12 de Octubre
Unidad Multidisciplinar de Hipertensión Pulmonar

Madrid
MADRID
Estudio Fase III, aleatorizado, abierto de Ponatinib frente a Imatinib en pacientes adultos con Leucemia Mieloide Crónica de nuevo diagnóstico en Fase Crónica (finalizado)
Hospital Universitario 12 de Octubre
Servicio de Hematología y Hemoterapia

Madrid
MADRID
Estudio en Fase III, aleatorio, abierto, multicéntrico, para evaluar la eficacia y seguridad de Nilotinib respecto a Imatinib en pacientes adultos con tumores estromales gastrointestinales (GIST) no resecables o metastásicos (completado)
Hospital Universitario La Paz
Servicio de Oncología Médica

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR
IMPRES: A 24-week Randomized Placebo-controlled, Double-blind Multi-centre Clinical Trial Evaluating the Efficacy and Safety of Oral QTI571 as an add-on Therapy in the Treatment of Severe Pulmonary Arterial Hypertension: Imatinib in Pulmonary Arterial Hypertension, a Randomized, Efficacy Study (PhaseIII)
Institution: Information not provided - FR

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR
ENESTcmr - An Open Label, Randomized Study of Nilotinib vs. Standard Imatinib (400/600 mg QD) Comparing the Kinetics of Complete Molecular Response for CML-CP Patients with Evidence of Persistent Leukemia by RQ-PCR (Phase III) - FR
Institution: Information not provided - FR

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR
IMPRES Extension - An extension study to QTI571A2301 to evaluate the longterm safety, tolerability and efficacy of oral QTI571 (imatinib) in the treatment of severe pulmonary arterial hypertension(Phase III) - FR
Institution: Information not provided - FR

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR
A Dose-finding Phase Ib Multicenter Study of Imatinib in Combination With the Oral Phosphatidyl-inositol 3-kinase (PI3K) Inhibitor BYL719 in Patients With Gastrointestinal Stromal Tumor (GIST) Who Failed Prior Therapy With Imatinib and Sunitinib - FR
Institution: Information not provided - FR

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR
A Non-randomized, Open-label Study to Characterize the Pharmacokinetics (PK) of Glivec/Gleevec® (Imatinib Mesylate) in Pediatric (Age Range 1 to Less Than 4 Years) Patients With Chronic Myeloid Leukemia (CML) or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ ALL) or Other Glivec/ Gleevec® Indicated Hematological Disorders (HES, CEL, MDS/ MPN) - FR
Institution: Information not provided - FR

AUVERGNE-RHONE-ALPES
LYON

ImadGist : A Randomized Multicenter Phase III Trial Evaluating the Interest of Imatinib Treatment Maintenance or Interruption After 3 Years of Adjuvant Treatment in Patients With Gastrointestinal Stromal Tumours (GIST)
CLCC Léon Bérard
Cancérologie médicale - Sarcomes et GIST, Tumeurs rares

BRETAGNE
RENNES
ESPHALL: An open-label, randomized phase II-study to compare the safety and efficacy of imatinib with chemotherapy in pediatric patients with Ph+/BCR-ABL+ acute lymphoblastic leukemia (Ph+ALL) - FR
CHU de Rennes - Hôpital Sud
Consultations d'hémato-oncologie pédiatrique

NOUVELLE AQUITAINE
BORDEAUX

MIM : Phase III multicentric trial to evaluate the efficacy of a strategy of dose determination of imatinib mesilate on molecular response in patients with chronic phase of Chronic Myeloid Leukemia treated with imatinib mesilate 400 mg/day for two years, with complete cytogenetic response for at least one year.
CLCC Institut Bergonié
Département d'oncologie médicale - Sarcomes

NOUVELLE AQUITAINE
PESSAC

An Open Label, Multi-center Imatinib Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Imatinib Study and Are Judged by the Investigator to Benefit From Continued Imatinib Treatment - FR
CHU de Bordeaux-GH Sud - Hôpital Haut-Lévêque
Service d'hématologie et thérapie cellulaire

NOUVELLE AQUITAINE
PESSAC
STIM 2 : Multicenter Trial Estimating the Persistence of Molecular Remission in Chronic Myeloid Leukaemia in Long Term After Stopping Imatinib
CHU de Bordeaux-GH Sud - Hôpital Haut-Lévêque
Laboratoire d'Hématologie - Secteur de cytogénétique et biologie moléculaire

CAMPANIA
NAPOLI

Sustained Treatment-free Remission in BCR-ABL+ Chronic Myeloid Leukemia: a Prospective Study Comparing Nilotinib Versus Imatinib With Switch to Nilotinib in Absence of Optimal Response. SUSTRENIM Study - GIMEMA CLM1415
Azienda Ospedaliera Universitaria "Federico II"
U.O. di Ematologia e Trapianto di Cellule Staminali Emopoietiche

EMILIA ROMAGNA
ADDRESS: NOT PROVIDED - IT
International phase 3 trial in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) testing imatinib in combination with two different cytotoxic chemotherapy backbones - EsPhALL2017/COGAALL1631 - IT
Institution: Information not provided - IT

LOMBARDIA
MONZA
Long term side effects of imatinib on Chronic Myeloid Leukemia (CLM) patients.
ASST Monza - Ospedale San Gerardo
Unità di Ricerca Clinica

LOMBARDIA
ROZZANO
A Phase II Study of the Combination of Gemcitabine and Imatinib Mesylate in Pemetrexed-pretreated Patients With Malignant Pleural Mesothelioma
IRCCS Istituto Clinico Humanitas
U.O. Oncologia Medica ed Ematologia

MARCHE
ANCONA
Low-dose oral Imatinib in the treatment of Scleroderma pulmonary involvement: a phase II pilot sutdy
Università Politecnica delle Marche - Polo Didattico
Istituto di Clinica Medica

Zuid-Holland
ROTTERDAM
Reduced intensity chemotherapy given with and without Imatinib Mesylate in patients >/= 60 years considered unfit for standard chemotherapy with previously untreated Acute Myeloid Leukemia (AML) and refractory anemia with excess of Blasts (RAEB, RAEB-T); A randomized phase II study.
Erasmus MC - Erasmus Medisch Centrum
Afdeling Hematologie

Glasgow
GLASGOW
Dasatinib in Chronic Myelogenous Leukemia or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemic Subjects Who Are Experiencing Clinical Benefit on Current START or CA180-039 Protocols: Long Term Safety and Efficacy Analysis (Phase II) - UK
University of Glasgow, Kelvin Building
College of Medical, Veterinary & Life Sciences

Glasgow
GLASGOW

Clinical trial for patients with TKI resistant chronic myeloid leukaemia in chronic or accelerated phase -GB
University of Glasgow, Kelvin Building
The University of Glasgow (Headquarters)

Greater London
LONDON
Dasatinib in Chronic Myelogenous Leukemia or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemic Subjects Who Are Experiencing Clinical Benefit on Current START or CA180-039 Protocols: Long Term Safety and Efficacy Analysis (Phase II) - UK
Hammersmith Hospital
Leukaemia Cytogenetics Unit

Greater London
SURREY
An Open Label, Multi-center Imatinib Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Imatinib Study and Are Judged by the Investigator to Benefit From Continued Imatinib Treatment - GB
The Royal Marsden
Royal Marsden NHS Foundation Trust

Greater London
UXBRIDGE
A Randomized, Placebo-controlled, Double-blind Study to Investigate the Effects of the Tyrosine Kinase Inhibitor Imatinib on Pulmonary Vascular Dysfunction in a Human Experimental Model of Acute Lung Injury
PAREXEL International Limited

Greater Manchester
ADDRESS: NOT PROVIDED - UK
CAMN107G2301: A randomized, open-label, multi-center phase III study to evaluate the efficacy and safety of nilotinib versus imatinib in adult patients with unresectable or metastatic gastrointestinal stromal tumors (GIST) - UK
Institution: Information not provided - UK

Greater Manchester
ADDRESS: NOT PROVIDED - UK
IMPRES Extension:An extension study to QTI571A2301 to evaluate the longterm safety, tolerability and efficacy of oral QTI571 (imatinib) in the treatment of severe pulmonary arterial hypertension (Phase III) - UK
Institution: Information not provided - UK

Greater Manchester
MANCHESTER
Intermediate and high risk localized, completely resected, gastrointestinal stromal tumors (GIST) expressing KIT receptor: a controlled randomized trial on adjuvant Imatinib mesylate (Glivec) versus no further therapy after complete surgery (Phase III) - UK
The Christie, NHS Foundation Trust
The Christie NHS Foundation Trust

Merseyside
WIRRAL
ITEM: A phase II study of Imatinib in the treatment of patients with metastatic uveal melanoma
The Clatterbridge Cancer Centre NHS Foundation Trust
The Clatterbridge Cancer Centre

Strathclyde
GLASGOW
Intermediate and high risk localized, completely resected, gastrointestinal stromal tumors (GIST) expressing KIT receptor: a controlled randomized trial on adjuvant Imatinib mesylate (Glivec) versus no further therapy after complete surgery (Phase III) - UK
NHS Greater Glasgow and Clyde Corporate HQ
Greater Glasgow and Clyde NHS Board

Surrey
CAMBERLEY
A phase III multi-center, open label, randomised study of optimised imatinib versus nilotinib in adult patients with newly diagnosed Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia in chronic phase (CML-CP) - UK
Novartis Pharmaceuticals UK Limited
Novartis Pharmaceuticals

Tyne & Wear
NEWCASTLE UPON TYNE
Dasatinib in Chronic Myelogenous Leukemia or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemic Subjects Who Are Experiencing Clinical Benefit on Current START or CA180-039 Protocols: Long Term Safety and Efficacy Analysis (Phase II) - UK
University of Newcastle
University of Newcastle Upon-Tyne

Suisse Alémanique
ZÜRICH

International Phase 3 Trial in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ALL) Testing Imatinib in Combination With Two Different Cytotoxic Chemotherapy Backbones - CH
Universitäts - Kinderspital Zürich - Eleonorenstiftung
Onkologie
Ensayo(s) clínico(s) multinacional(es)

EMILIA ROMAGNA
ADDRESS: NOT PROVIDED - IT
International phase 3 trial in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) testing imatinib in combination with two different cytotoxic chemotherapy backbones - EsPhALL2017/COGAALL1631
Institution: Information not provided - IT

Suisse Alémanique
BASEL
A Randomized, Open Label, Multi-center Phase III Study to Evaluate the Efficacy and Safety of Nilotinib Versus Imatinib in Adult Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors (GIST) (coordination)
Novartis International AG

Suisse Alémanique
BASEL

Suisse Alémanique
BASEL