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Terminated research projects = Funded by an IRDiRC member = Member of a ERN =

Research projects

BELGIUM

HAINAUT
GOSSELIES

Enroll-HD: A Prospective Registry Study in a Global Huntington's Disease Cohort - BE
Institut de Pathologie et de Génétique
Département de Génétique Clinique - Institut de Pathologie et de Génétique (IPG)

BELGIUM

VLAAMS BRABANT
LEUVEN

CANADA

Alberta
EDMONTON

Funded by an IRDiRC memberTherapeutic role of ganglioside GM1 in Huntington's disease
University of Alberta
Department of Pharmacology

CANADA

Colombie-Britannique
VANCOUVER

CANADA

Colombie-Britannique
VANCOUVER

Funded by an IRDiRC memberAltered balance of synaptic/extrasynaptic NMDA receptor signaling in Huntington disease
University of British Columbia
Centre for Huntington Disease- UBC Hospital

CANADA

Ontario
HAMILTON

Funded by an IRDiRC memberElucidating the Protective Mechanism of Phospho-N17 Huntingtin in Huntington's disease
McMaster University
Biochemistry and Biomedical Sciences

CANADA

Ontario
HAMILTON

CANADA

Ontario
TORONTO

Funded by an IRDiRC memberDNA repair proteins as modifiers of CAG repeat instability in Huntington's disease
The Hospital for Sick Children
Genetics and Genome Biology

CANADA

Québec
QUÉBEC

Funded by an IRDiRC memberPreventing pathological protein spread in Huntington's disease: relevance to pathology and treatment
CHUQ - (CHUL) Centre hospitalier de l'Université Laval
Axe Neuosciences, CHUL

CZECH REPUBLIC

Capital City Prague
PRAHA 2

Markers of mitochondrial dysfunction in presymptomatic and early stages of Huntington's disease
Vseobecna fakultni nemocnice a 1. lekarska fakulta UK
Neurologicka klinika

FRANCE

AUVERGNE-RHONE-ALPES
LA TRONCHE

FRANCE

AUVERGNE-RHONE-ALPES
SAINT-MARTIN-D'HÈRES

FRANCE

HAUTS-DE-FRANCE
ADDRESS: NOT PROVIDED - FR

FRANCE

HAUTS-DE-FRANCE
VILLENEUVE D'ASCQ

Funded by an IRDiRC memberDyadic dynamics of couples in Huntington disease
Université Lille 3
Equipe Dynamique Emotionnelle et Pathologies

FRANCE

ILE-DE-FRANCE
FONTENAY-AUX-ROSES

Funded by an IRDiRC memberInnovative Imaging and BIO Cognitive Markers to Predict the Progression of Huntington's Disease
CEA - Commissariat à l'Energie Atomique
Laboratoire des Maladies Neurodégénératives

FRANCE

ILE-DE-FRANCE
PARIS

Funded by an IRDiRC memberEfficient Gene and Sterol regulations by gene transfer for striatal protection in Huntington's Disease
AP-HP.Sorbonne Université - Hôpital de la Pitié-Salpêtrière
APHP.Sorbonne Université, Hôpital de la Pitié-Salpêtrière

FRANCE

ILE-DE-FRANCE
PARIS

Development of therapeutic strategies for human degenerative diseases
Centre Paul Broca
Biologie et pathologie du neurone

FRANCE

ILE-DE-FRANCE
PARIS

Funded by an IRDiRC memberCell-Type-Specific Gene and Sterol Profiling following CYP46A1 gene therapy in Huntington disease
Université Pierre et Marie Curie - Paris 6 - UPMC
Neuroscience Paris Seine (CNRS UMR8246/Inserm U1130/UMPC UMCR18)

FRANCE

ILE-DE-FRANCE
PARIS

Funded by an IRDiRC memberBrain response to Huntington's disease: role of small vesicles
Université Pierre et Marie Curie - Paris 6 - UPMC
Adaptation Biologique et Vieillissement

FRANCE

PROVENCE-ALPES-COTE D'AZUR
MARSEILLE

GERMANY

Baden-Württemberg
ULM

Funded by an IRDiRC memberREPETOMICS: Genomic Instability of Expanded Repeats in HD and ALS/FTD -DE
Universitäts- und Rehabilitationskliniken Ulm (RKU)
Klinik für Neurologie

GERMANY

Bayern
NEUHERBERG

ITALY

EMILIA ROMAGNA
BOLOGNA

Enroll-HD - A Prospective Registry Study in a Global HD Cohort - IT
Università di Bologna - Istituto di Clinica Neurologica
Laboratorio di Neurogenetica

ITALY

LAZIO
ROMA

Funded by an IRDiRC memberAnalysis of apoptosis in neurodegenerative diseases by apaf1 conditional mutagenesis (terminated)
Università degli Studi di Roma Tor Vergata
Laboratorio di Genetica delle Popolazioni

ITALY

LOMBARDIA
MILANO

ITALY

LOMBARDIA
MILANO

Funded by an IRDiRC memberTargeting neurons with cholesterol. How can it change the future of Huntington Disease patients
Università degli Studi di Milano - Scienze Biomolecolari e Biotecnologiche
Dipartimento di Bioscienze

PORTUGAL

CENTRO
COIMBRA

Analysis of transcription deregulation in brain and peripheral Huntington disease models - influence of modulating histone deacetylases.
Universidade de Coimbra - Centro de Neurociências e Biologia Celular
Grupo de Disfunção Mitocondrial e Morte Celular

SPAIN

Cataluña
BARCELONA

Funded by an IRDiRC memberBiological-guided development and validation of specific cognitive assessment instruments in Huntington's disease
IIB Sant Pau - Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

SPAIN

Cataluña
BARCELONA

Gliotransmitters and Cannabinoid Receptors at the hub of cognitive and synaptic plasticity impairments in Huntington's disease
Universitat de Barcelona. Campus de Medicina - Clínic August Pi i Sunyer
Departamento de Biología Celular, Inmunología y Neurociencias

SPAIN

Comunidad Valenciana
VALENCIA

Funded by an IRDiRC memberModulating the activity of genes controlling fat metabolism as a therapeutic strategy in Huntington disease
Hospital Universitario y Politécnico La Fe
Fundación para la Investigación del Hospital Universitari La Fe

SPAIN

Madrid
MADRID

Gliotransmitters and Cannabinoid Receptors at the hub of cognitive and synaptic plasticity impairments in Huntington's disease
Universidad Complutense de Madrid. Facultad de Medicina
Departamento de Bioquímica y Biología Molecular (Medicina)

SWEDEN

Region Skåne
LUND

BAGADILICO: Hypothalamic changes and biomarkers in Huntington's disease
Lunds Universitet
Department of Experimental Medical Science

SWEDEN

Region Skåne
LUND

SWEDEN

Region Stockholm
SOLNA

The functional organisation of the brain
Karolinska Institutet
Department of Clinical Neuroscience (CNS)

SWITZERLAND

Suisse Alémanique
ZÜRICH

SWITZERLAND

Suisse Romande
LAUSANNE

Funded by an IRDiRC memberToward gene repair for Huntington's disease
Centre Hospitalier Universitaire Vaudois CHUV
Laboratoire des neurothérapies et neuromodulation

UNITED KINGDOM

Avon
BRISTOL

UNITED STATES

Maryland
BETHESDA

Funded by an IRDiRC memberDeveloping inhibitors for PIP4Kgamma for Huntington's disease
National Center for Advancing Translational Sciences (NCATS-NIH)
Chemistry Technologies

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberNanocarriers designed to deliver nucleic acids to brain
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberEpigenetic pathology and therapy in huntington's disease
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberExtrinsic mechanisms governing injury-induced axon degeneration
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberUsing a disease-affected cell to synthesize its own drug
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberCortical pathophysiology in mouse models of huntington's disease
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberGenetic correction of mutant huntingtin in vivo
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberHuntington's disease: a novel developmental oligodendrogliopathy
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberRhes-sumo circuitry in huntington's disease pathogenesis
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberStructure of triplet repeat mrna in neurodegenerative disease
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberCrmp2; mitochondria; and huntington's disease
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberControl of excitatory synapse formation by huntingtin
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberN-terminal huntingtin and huntington disease neuropathology
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

SPAIN

Asturias
OVIEDO

Funded by an IRDiRC memberThe emergent pathogenic role for the intermediate CAG repeats in the HTT gene: from the neuropathological evidences to the molecular findings
Fundación para la Investigación Biosanitaria del Principado de Asturias
FINBA: Fundación para la Investigación Biosanitaria del Principado de Asturias

SPAIN

Cataluña
BARCELONA

Advanced genomics and lipidomics for identifying novel causes of inherited movement disorders
Instituto de Química Avanzada de Cataluña
Unidad de Investigación en Moléculas Bioactivas

SPAIN

Cataluña
L'HOSPITALET DE LLOBREGAT

Advanced genomics and lipidomics for identifying novel causes of inherited movement disorders
IDIBELL - Instituto de Investigación Biomédica de Bellvitge
Laboratorio de Enfermedades Neurometabólicas

SPAIN

País Vasco
SAN SEBASTIÁN

Advanced genomics and lipidomics for identifying novel causes of inherited movement disorders
Instituto de Investigación Sanitaria Biodonostia
Área de Neurociencias

ITALY

LAZIO
ROMA

Funded by an IRDiRC memberDiverse rare diseases caused by functional dysregulation of Rho GTPase-related proteins
ISS - Istituto Superiore di Sanità
Centro Nazionale Malattie Rare

SPAIN

Cataluña
BARCELONA

SPAIN

Cataluña
BARCELONA

Igenco: In-Depth genomics and cross-omics analysis for undiagnosed rare diseases on a user-friendly collaborative platform
ISGlobal - Instituto de Salud Global de Barcelona
Programa de investigación en Enfermedades no transmisibles y medio ambiente

CANADA

Colombie-Britannique
VICTORIA

CANADA

Ontario
TORONTO

SPAIN

Cataluña
BARCELONA

Catalan Interhospital Network of Genetic Variants to improve genetic diagnosis in rare diseases
Centro de Regulación Genómica
Archivo europeo de genomas y fenomas del CRG

SPAIN

Cataluña
BARCELONA

SPAIN

Cataluña
BARCELONA

SPAIN

Cataluña
BARCELONA

SPAIN

Cataluña
ESPLUGUES DE LLOBREGAT

Federated network for functional genomics of undiagnosed and rare diseases, RareFunction
Fundació Sant Joan de Déu - Institut de Recerca Sant Joan de Déu
Grupo de investigación en Neurogenética y Medicina Molecular

SPAIN

Cataluña
ESPLUGUES DE LLOBREGAT

SPAIN

Cataluña
L'HOSPITALET DE LLOBREGAT

Catalan Interhospital Network of Genetic Variants to improve genetic diagnosis in rare diseases
Hospital Universitari de Bellvitge
Unidad de Genética Molecular

SPAIN

Comunidad Valenciana
VALENCIA

Funded by an IRDiRC memberClinical studies, genetic basis and prognosis biomarkers in rare neurodegenerative diseases
Centro de Investigación Príncipe Felipe (CIPF)
CIPF: Centro de Investigación Príncipe Felipe

SPAIN

Madrid
MADRID

Funded by an IRDiRC memberIdentification of new genes causing rare diseases in pediatric patients, searching of genetic pharmacological targets, and drugs discovery, the steps for a personalized medicine
Instituto de Investigación Hospital 12 de Octubre
Grupo de investigación en enfermedades raras, mitocondriales y neuromusculares

Multicentric Research projects