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76 Ergebnis(se)
Förderung durch ein IRDiRC-Mitglied = ERN-Mitglied =
Forschungsprojekt(e)

County Dublin
DUBLIN
Conformational triggers, Mechanisms and Pathways for Neurodegenerative Disease
Trinity College Dublin
Institute of Neuroscience

NORTE
PORTO
SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias
Instituto de Biologia Molecular e Celular
Centro de Genética Preditiva e Preventiva

NORTE
PORTO
Clinical implications of genetic factors causing neurodegenerative diseases characterized by movement or cognitive dysfunction.
Instituto de Biologia Molecular e Celular
Unidade de Investigaçăo Genética e Epidemiológica em Doenças Neurológicas

NORTE
PORTO
Mapping and identification of new disease genes in autosomal dominant spinocerebellar ataxias
Instituto de Biologia Molecular e Celular
Unidade de Investigaçăo Genética e Epidemiológica em Doenças Neurológicas

NORTE
PORTO
SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias
Instituto de Biologia Molecular e Celular
Unidade de Investigaçăo Genética e Epidemiológica em Doenças Neurológicas

NORTE
SANTA MARIA DA FEIRA
SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias
Hospital Săo Sebastiăo
Serviço de Neurologia

Comunidad Valenciana
VALENCIA
Clinical studies, genetic bases and prognostic biomarkers in rare neurodegenerative diseases
Centro de Investigación Príncipe Felipe (CIPF)
Unidad de Genética y Genómica de Enfermedades Neuromusculares y Neurodegenerativas

Greater London
LONDON
Endogenous Cerebellar Human Stem Cells and their Potential Neuroregenerative Role in Inherited Ataxias
Barts and The London School of Medicine and Dentistry
Centre for Neuroscience and Trauma

Lothian
EDINBURGH
Developing non-invasive therapeutic technology to improve motor coordination in cerebellar ataxias
PMARC - The University of Edinburgh
Perception-Movement-Action Research Consortium

Lothian
EDINBURGH
Developing non-invasive therapeutic technology to improve motor coordination in cerebellar ataxias
School of Informatics, The University of Edinburgh
Human Communication Research Centre

Arizona
PHOENIX
The etiology of inherited neurological diseases
Phoenix Children's Hospital
Barrow Neurological Institute

Baden-Württemberg
TÜBINGEN
SCA-CYP: Gentherapie bei Zerebellären Ataxien: Wiederherstellung des Cholesterin-Metabolismus durch Beeinflussung der Cholesterin-24S-hydroxylase (CYP46A1) im Gehirn (partner No 3)
Institut für Medizinische Genetik und angewandte Genomik Tübingen
Institut für Medizinische Genetik und angewandte Genomik

Bayern
NEUHERBERG
PolyQure: Ursächliche Behandlung von Polyglutamin-Erkrankungen durch Inhibition von TRMT2A - Hochdurchsatz- und strukturbiologische Verfahren
Helmholtz Zentrum München
Institut für Strukturbiologie - AG Niessing

Hessen
FRANKFURT AM MAIN
CAG102-Knock-In Modell für die Spinocerebelläre Ataxie Typ 2
Neurologische Universitätsklinik
Klinik für Neurologie

Nordrhein-Westfalen
BOCHUM
TreatPolyQ: Allel-spezifische Reduzierung der mutierten Polyglutamin-Proteine zur Behandlung der Huntington-Krankheit, spinozerebellären Ataxie Typ 3 und spinozerebellären Ataxie Typ 7 (Koordinator)
Ruhr-Universität Bochum
Humangenetik Bochum

Nordrhein-Westfalen
BONN
Neuro2D3 - Standardisierte Systeme zur Modellierung spät einsetzender neurologischer Erkrankungen und Wirkstoffscreening in 2D und 3D Kulturen
Universitätsklinikum Bonn (AöR)
Institut für Rekonstruktive Neurobiologie

GRAND-EST
ILLKIRCH-GRAFFENSTADEN
Study of proliferative and regenerative potential of the photoreceptors in a SCA7 mouse model, a disease by polyglutamine expansion
Institut de génétique et de biologie moléculaire et cellulaire - IGBMC
Département Médecine translationnelle et neurogénétique

ILE-DE-FRANCE
PARIS
BIOSCA:Biomarkers in Autosomal Dominant Cerebellar Ataxia
APHP.Sorbonne Université, Hôpital de la Pitié-Salpętričre
UF de Neurogénétique Moléculaire et Cellulaire

OCCITANIE
MONTPELLIER
Non Invasive Prenatal Diagnosis on Isolated Circulating Fetal Trophoblastic Cells (CFTC) for Triplet Repeat Diseases
CHU de Montpellier - IURC
Laboratoire de Génétique Moléculaire

LOMBARDIA
MILANO
A drosophila model to study the neurodegenerative disease Dentatorubral-pallidoluysian atrophy
IRCCS Ospedale San Raffaele
Divisione di Genetica e Biologia Cellulare - Dipartimento di Genomica Funzionale

JAPAN
NIIGATA
Development of therapeutic strategy for DRPLA based on gene silencing and genome editing.
Brain Research Institute, Niigata University
Department of Neurology

JAPAN
OSAKA
Development of molecular therapy for non-coding repeat diseases targeting unconventional repeat associated non- ATG (RAN) translation
Osaka University Graduate School of Medicine
Department of Neurotherapeutics

JAPAN
TOKYO
Transgenic monkey model of the polyglutamine diseases recapitulating progressive neurological symptoms: establishing pathological mechanism and effective treatment for spinocerenellar ataxia type 3
National Center of Neurology and Psychiatry
Department of Neurophysiology

JAPAN
TOKYO
Developing antisense ol igonucleotide therapy targeting bidirectional transcription underlying an inherited neurodegenerative disease.
Tokyo Medical and Dental University Medical Hospital
Center for Personalized Medicine for Healthy Aging

JAPAN
TOKYO
Gene therapy against SCA1 based on the molecular pathomechanism
Tokyo Medical and Dental University Medical Research Institute
Department of Neuropathology

Alberta
CALGARY
Muscle rehabilitation of cerebral palsy patients recieving botulinum toxin type-A (Botox) treatments
University of Calgary
Faculty of Kinesiology

Utrecht
ADDRESS: NOT PROVIDED - NL
Targeting ataxin-1 in spinocerebellar ataxia type 1 (SCA1) patient-specific induced pluripotent stem cell-derived neurons
Institution: Information not provided - NL

CENTRO
ADDRESS: NOT PROVIDED - PT
Does the transplantation of mutant ataxin-3-depleted patient-derived NSC alleviates Machado Joseph disease (MJD)?
Institution: Information not provided - PT

CENTRO
ADDRESS: NOT PROVIDED - PT
Exomes as gene delivery vectors for the treatment of machado-Joseph disease/spinocerebellar ataxia type 3
Institution: Information not provided - PT

CENTRO
BRAGA
Screening of therapeutic compounds in a C. elegans model of Machado-Joseph disease
Universidade do Minho
Grupo de Neurocięncias

CENTRO
COIMBRA
The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors.
Centro de Neurocięncias da Universidade de Coimbra
Departmento de vectores e terapia génica

CENTRO
COIMBRA
Regulation by phosphorylation of ataxin-3, the mutated protein in Machado Joseph Disease
Centro de Neurocięncias da Universidade de Coimbra
Glutamatergic Synapses: Formation and regulation of synapses

NORTE
PORTO
A peptide aptamer-based approach to neurodegenerative disorders.
Instituto de Biologia Molecular e Celular
Protein Crystallography Group

NORTE
PORTO
CACNA1A gene involvement in cognition and synaptic function in calcium channel disease.
Instituto de Biologia Molecular e Celular
Unidade de Investigaçăo Genética e Epidemiológica em Doenças Neurológicas

NORTE
PORTO
Search for disease modifiers in spinocerebellar ataxias: human and animal-based approaches.
Instituto de Biologia Molecular e Celular
Unidade de Investigaçăo Genética e Epidemiológica em Doenças Neurológicas

Region Stockholm
STOCKHOLM
The role of an atrophin-brakeless protein complex in gene regulation and neurodegeneration in particularly
Stockholm University
Department of Molecular Biosciences, The Wenner-Gren Institute (MBW)

Region Stockholm
STOCKHOLM
Investigation of mechanisms affecting protein aggregation and neuronal toxicity in polyglutamine diseases using spinocerebellar ataxia type 7 (SCA7) as a model system
Stockholm University
Department of Neurochemistry

Suisse Alémanique
BERN
Swiss Primary Hypersomnolence and Narcolepsy Cohort Study
University Hospital Inselspital
Universitätsklinik für Neurologie

Suisse Romande
LAUSANNE
TreatPolyQ: Allele-specific lowering of mutant polyQ proteins as treatment for Huntington disease, spinocerebellar ataxia type 3 and spinocerebellar ataxia type 7 - CH
Centre Hospitalier Universitaire Vaudois CHUV
Laboratoire des neurothérapies et neuromodulation

Madrid
MADRID
RAREGenomics: Network of Genomic, Functional, Clinical and Therapeutic Resources for the Study of Rare Neurological Diseases
Hospital Universitario Fundación Jiménez Díaz
Servicio de Genética Clínica

Washington
ADDRESS: NOT PROVIDED - US
Natural history of spinocerebellar ataxia type 7 (sca7)
Institution: Information not provided - US

Washington
ADDRESS: NOT PROVIDED - US
Unraveling the mechanisms of motor neuron degeneration if spinocerebellar ataxia; type 1
Institution: Information not provided - US

ILE-DE-FRANCE
PARIS
STaHR : Stimulation of Targeted Homologous Recombination for Gene Therapy - FR
Muséum National d'Histoire Naturelle
Laboratoire Structure et Instabilité des Génomes - INSERM U1154 - CNRS 7196

PAYS DE LA LOIRE
NANTES
FROGH : FRench Regional Origins in Genetics for Health - FR
Institut de Recherche en Santé - Université de Nantes
L'Institut du thorax - Inserm UMR 1087 / CNRS UMR 6291

LAZIO
ROMA
Diverse rare diseases caused by functional dysregulation of Rho GTPase-related proteins
ISS - Istituto Superiore di Sanitŕ
Centro Nazionale Malattie Rare

JAPAN
AICHI
Management ofthe clinical diagnostic centre for rare intractable diseases with genome instability and development of potential therapeutic medicine
Research Institute of Environmental Medicine, Nagoya University

JAPAN
AICHI
Establishment of the Next-generation Muti-omics Clinical Diagnostic Centre for rare intractable diseases with genome instability
Research Institute of Environmental Medicine, Nagoya University

JAPAN
TOKYO
Formation of integrated omics analysis base of refractory diseases in children and perinatal period
National Center for Child Health and Development
Research Institute

Ontario
TORONTO
Beyond the Genome: Transcriptome Based Diagnostics for Rare Diseases and Cancer
Hospital for Sick Children, Research Institute

Madrid
MADRID
Bioinformatics developments based on network and systems biology to identify new candidate genes for rare genetic diseases
Fundación Jiménez Díaz
Área de Genética y Genómica

Washington
ADDRESS: NOT PROVIDED - US
A powerful web-based discovery platform for rare disease genetics
Institution: Information not provided - US
Multizentrische Forschungsprojekte
- Institut für Medizinische Genetik und angewandte Genomik Tübingen
- Institut für Medizinische Genetik und angewandte Genomik
- Institut du Cerveau et de la Moelle épiničre (ICM) - Hôpital Pitié-Salpętričre
- Equipe "Bases moléculaires, physiopathologie et traitement des maladies neurodégénératives"
- Fondazione EBRI
- Istituto di Neurobiologia e Medicina Molecolare
- Institut für Medizinische Genetik und angewandte Genomik Tübingen
- Institut für Medizinische Genetik und angewandte Genomik
- Zentralinstitut für Seelische Gesundheit
- Abteilung Translationale Hirnforschung
- Institut für Medizinische Genetik und angewandte Genomik Tübingen
- Institut für Medizinische Genetik und angewandte Genomik
- Institut für Medizinische Genetik und angewandte Genomik Tübingen
- Institut für Medizinische Genetik und angewandte Genomik
- Institut für Medizinische Genetik und angewandte Genomik Tübingen
- Institut für Medizinische Genetik und angewandte Genomik
- Ruhr-Universität Bochum
- Humangenetik Bochum
- Universitätsklinikum Bonn (AöR)
- Klinik und Poliklinik für Neurologie
- Universitätsklinikum Bonn (AöR)
- Klinik und Poliklinik für Neurologie
- Muséum National d'Histoire Naturelle
- Laboratoire Structure et Instabilité des Génomes - INSERM U1154 - CNRS 7196
- Institut de Recherche en Santé - Université de Nantes
- L'Institut du thorax - Inserm UMR 1087 / CNRS UMR 6291
- IRCCS Ospedale Pediatrico Bambino Gesů - SEDE GIANICOLO
- Servizio Clinico di Consulenza Genetica
- University of British Columbia
- Maternal Infant Child and Youth Research Network
- Hospital Universitari de Bellvitge
- Unidad de Neuropatología
- Camden Mews Day Hospital
- North Thames DeNDRoN, Camden & Islington Mental Health Trust
- Wythenshawe Hospital
- Dementias & Neurodegenerative Diseases Research Network
- Moorgreen Hospital
- Memory & Assessment & Research Centre
- Julian Hospital
- Churchill Hospital
- Fulbrook Centre
- St Martin's Hospital
- Research Institute for the Care of the Elderly (RICE)
- Newcastle General Hospital
- Wolfson Research Centre
- Alzheimer Europe Office
- Max-Planck-Institut für experimentelle Medizin
- Abteilung Molekulare Neurobiologie

Baden-Württemberg
TÜBINGEN
EUROSCA: European integrated project on spinocerebellar ataxias (FINISHED)

ILE-DE-FRANCE
PARIS
SPATAX: European network for hereditary spinocerebellar degenerative disorders

LAZIO
ROMA
ITASPA: clinical and genetic analysis of spastic paraplegias

Baden-Württemberg
TÜBINGEN
Neuromics: Integrated European -omics research project for diagnosis and therapy in rare neuromuscular and neurodegenerative diseases

Baden-Württemberg
MANNHEIM
PPPT-MJD: towards the understanding of pathological protein processing and toxicity in Machado-Joseph Disease

Baden-Württemberg
TÜBINGEN
RATSTREAM: European project on the characterisation of transgenic rat models for neurodegenerative and psychiatric diseases: Automated home cage analyses, live imaging and treatment (FINISHED)

Baden-Württemberg
TÜBINGEN
TreatPolyQ: Industrial Academic Initial Training Network (Itn) Towards Treatment Of Polyglutamine Diseases -terminated-

Baden-Württemberg
TÜBINGEN
PhenoRat: European Industrial Doctorate on the generation, characterisation and validation of transgenic rat models of two neurodegenerative diseases: Huntington's disease and spinocerebellar ataxia type 17

Nordrhein-Westfalen
BOCHUM
TreatPolyQ: Allel-spezifische Reduzierung der mutierten Polyglutamin-Proteine zur Behandlung der Huntington-Krankheit, spinozerebellären Ataxie Typ 3 und spinozerebellären Ataxie Typ 7

Nordrhein-Westfalen
BONN
RISCA: prospective study of individuals at risk for spinocerebellar ataxia type 1, type 2, type 3 and type 6 (SCA1, SC2, SCA3, SCA6)

Nordrhein-Westfalen
BONN
ESMI: European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative

ILE-DE-FRANCE
PARIS
STaHR : Stimulation of Targeted Homologous Recombination for Gene Therapy

PAYS DE LA LOIRE
NANTES
FROGH : FRench Regional Origins in Genetics for Health

LAZIO
ROMA
UnRareNet: a muticenter collaborative research network for the identification and study of rare undiagnosed patients (completed)

Colombie-Britannique
VANCOUVER
Maternal Infant Child and Youth Research Network (MICYRN)

Cataluńa
L'HOSPITALET DE LLOBREGAT
CIEN: Spanish Network for Cooperative Research in Neurological diseases

Greater London
LONDON
DENDRON - north Thames region: Dementias & Neurodegenerative Diseases Research Network

Greater Manchester
MANCHESTER
DENDRON - north west region: Dementias & Neurodegenerative Diseases Research Network

Hampshire
SOUTHAMPTON
DENDRON - south coast region: Dementias & Neurodegenerative Diseases Research Network

Norfolk
NORWICH
DENDRON - east Anglia region: Dementias & Neurodegenerative Diseases Research Network

Oxfordshire
OXFORD
DENDRON - Thames valley region: Dementias & Neurodegenerative Diseases Research Network

Somerset
BATH
DENDRON - south west region: Dementias & Neurodegenerative Diseases Research Network

Tyne & Wear
NEWCASTLE UPON TYNE
DENDRON - north east region: Dementias & Neurodegenerative Diseases Research Network

LUXEMBOURG
LUXEMBOURG
Alzheimer Europe: European database on rare forms of dementia

Niedersachsen
GÖTTINGEN