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Terminated research projects = Funded by an IRDiRC member = Member of a ERN =

Research projects

BELGIUM

VLAAMS BRABANT
LEUVEN

HDACALS: Investigating the therapeutic potential of inhibition of histone deacetylases in a FUS mouse model of ALS
UZ Leuven - Campus Gasthuisberg
Ludo Van Den Bosch Lab- VIB-KU Leuven Center for Brain & Disease Research

CANADA

Alberta
EDMONTON

Funded by an IRDiRC memberMRI biomarkers in ALS
University of Alberta
Department of Medicine, Division of Neurology

CANADA

Alberta
EDMONTON

Funded by an IRDiRC memberPromoting protection of functionally intact motor units in amyotrophic lateral sclerosis (ALS).
University of Alberta
Faculty of Physical Education and Recreation

CANADA

Colombie-Britannique
VANCOUVER

CANADA

Ontario
OTTAWA

Funded by an IRDiRC memberLoss of VAPB Function in Amyotrophic Lateral Sclerosis-8 (ALS8)
Ottawa Hospital Research Institute
Neuroscience

CANADA

Ontario
TORONTO

Funded by an IRDiRC memberThe TAR DNA-Binding Protein (TDP-43) and Amyotrophic Lateral Sclerosis
University of Toronto
Centre for Research in Neurodegenerative Disease

CANADA

Ontario
WATERLOO

Funded by an IRDiRC memberFolding and aggregation of ALS-associated mutant superoxide dismutases
University of Waterloo
Department of Chemistry

CANADA

Québec
ADDRESS: NOT PROVIDED - CA

CANADA

Québec
MONTRÉAL

Funded by an IRDiRC memberUnderstanding G3BP1 and stress granule dynamics in ALS pathogenesis
Centre Hospitalier de l'Université de Montréal
Département de biochimie et médecine moléculaire

CANADA

Québec
MONTRÉAL

Funded by an IRDiRC memberRegeneration of motor neurons controlling movement and respiration from embryonic stem cells
Montreal Neurological Institute and Hospital
McGill University

CANADA

Québec
MONTRÉAL

Funded by an IRDiRC memberRegulation of motor neuron identity and circuit development
Montreal Neurological Institute and Hospital
McGill University

CANADA

Québec
MONTRÉAL

FINLAND

Finland
HELSINKI

Funded by an IRDiRC memberCDNF and CDNF variants- novel therapy for ALS
Biocenter 1, University of Helsinki
Institute of Biotechnology

FRANCE

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR

FRANCE

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR

FRANCE

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR

FRANCE

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR

FRANCE

GRAND-EST
ILLKIRCH-GRAFFENSTADEN

Funded by an IRDiRC memberC9ORF72-ALS: Role of C9ORF72 in Amyotrophic Lateral Sclerosis
Institut de génétique et de biologie moléculaire et cellulaire - IGBMC
Département Médecine translationnelle et neurogénétique

FRANCE

GRAND-EST
ILLKIRCH-GRAFFENSTADEN

Funded by an IRDiRC memberStudy of new mutations in the C9ORF72 gene responsible for Amyotrophic Lateral Sclerosis
Institut de génétique et de biologie moléculaire et cellulaire - IGBMC
Département Médecine translationnelle et neurogénétique

FRANCE

GRAND-EST
STRASBOURG

Involvement of metabolic dysfunctions in the pathogenesis of amyotrophic lateral sclerosis
Faculté de médecine de Strasbourg - Louis Pasteur
Laboratoire de signalisations moléculaires et neurodégénérescence

FRANCE

GRAND-EST
STRASBOURG

Funded by an IRDiRC memberModulation of metabolic flexibility in Amyotrophic Lateral Sclerosis as a new therapeutic approach - FR
Faculté de médecine de Strasbourg - Louis Pasteur
Laboratoire de signalisations moléculaires et neurodégénérescence

FRANCE

GRAND-EST
STRASBOURG

Funded by an IRDiRC memberRole of CA-repeating microsatellites in FUS and TDP-43 related diseases
Faculté de médecine de Strasbourg - Louis Pasteur
Mécanismes centraux et périphériques de la Neurodégénérescence - INSERM U1118

FRANCE

GRAND-EST
STRASBOURG

Funded by an IRDiRC memberMuscle contribution to FUS-associated ALS: genetic and mechanistic insights - FR
Faculté de médecine de Strasbourg - Louis Pasteur
Mécanismes centraux et périphériques de la Neurodégénérescence - INSERM U1118

FRANCE

GRAND-EST
STRASBOURG

Funded by an IRDiRC memberDeciphering the mechanisms of repeat-associated non-AUG (RAN) translation in amyotrophic lateral sclerosis
IBMC - Institut de biologie moléculaire et cellulaire
Evolution des Systèmes d'Initiation de la Traduction chez les eucaryotes

FRANCE

GRAND-EST
STRASBOURG

Funded by an IRDiRC memberMAXOMOD: Multi-omic analysis of axono-synaptic degeneration in motoneuron disease - FR
Institut Pluridisciplinaire Hubert Curien
Spectrométrie de masse bio organique

FRANCE

HAUTS-DE-FRANCE
LILLE

Funded by an IRDiRC memberAssessment of the ethical and legal issues of the use of telemedicine in the support of patients with advanced stage Amyotrophic lateral sclerosis
GH de l'Institut Catholique de Lille - Hopital Saint Vincent de Paul
Institut catholique de Lille - ICL ETHICS EA 7446

FRANCE

ILE-DE-FRANCE
PARIS

Funded by an IRDiRC memberCell signaling, Reinnervation and Metabolism in Amyotrophic Lateral Sclerosis (CERMALS)
AP-HP.Sorbonne Université - Hôpital de la Pitié-Salpêtrière
Unité Nerf périphérique, Sclérose Latérale Amyotrophique (SLA)

FRANCE

ILE-DE-FRANCE
PARIS

Funded by an IRDiRC memberEfficacy, activity and safety of low-dose IL-2 (ld-IL-2) as a Treg enhancer for anti-neuroinflammatory therapy in newly diagnosed Amyotrophic Lateral Sclerosis (ALS) patients
AP-HP.Sorbonne Université - Hôpital de la Pitié-Salpêtrière
APHP.Sorbonne Université, Hôpital de la Pitié-Salpêtrière

FRANCE

ILE-DE-FRANCE
PARIS

Involvement of metabolic dysfunctions in the pathogenesis of amyotrophic lateral sclerosis
AP-HP.Sorbonne Université - Hôpital de la Pitié-Salpêtrière
Département de Neurologie - Pôle des Maladies du Système Nerveux

FRANCE

ILE-DE-FRANCE
PARIS

Funded by an IRDiRC memberDefining functional networks of genetic causes for ALS and related neurodegenerative disorders
Inserm-ANRS
Inserm-ANRS (Agence Nationale de Recherches sur le Sida et les Hépatites Virales)

FRANCE

ILE-DE-FRANCE
PARIS

Funded by an IRDiRC memberUsing PML nuclear body biology to identify potential AML treatment targets
Inserm-ANRS
Inserm-ANRS (Agence Nationale de Recherches sur le Sida et les Hépatites Virales)

FRANCE

ILE-DE-FRANCE
PARIS

Funded by an IRDiRC memberNew gene therapy approaches for familial forms of amyotrophic lateral sclerosis
Institut de Myologie - Hôpital Pitié-Salpêtrière
Centre de Recherche en Myologie

FRANCE

ILE-DE-FRANCE
PARIS

Funded by an IRDiRC memberAAV-mediated delivery of FGF as a therapeutic strategy for Amyotrophic Lateral Sclerosis
Institut de Myologie - Hôpital Pitié-Salpêtrière
Centre de Recherche en Myologie

FRANCE

ILE-DE-FRANCE
PARIS

Study of the interactions between microglial cells, macrophages and neurons from three axes in an animal model of amyotrophic lateral sclerosis
Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-Salpêtrière
Equipe "Bases moléculaires, physiopathologie et traitement des maladies neurodégénératives"

FRANCE

ILE-DE-FRANCE
PARIS

Funded by an IRDiRC memberDeciphering respective contributions of macrophages and microglia to motor neuron degeneration in Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis with microfluidic devices
Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-Salpêtrière
Equipe "Causes de la SLA et mécanismes de la dégénérescence motoneuronale"

FRANCE

ILE-DE-FRANCE
PARIS

Localisation and identification of causative genes for amyotrohic lateral sclerosis
Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-Salpêtrière
Equipe "Excitabilité, synapse & pathologies associées"

FRANCE

ILE-DE-FRANCE
PARIS

Funded by an IRDiRC memberAmyotrophic Lateral Sclerosis gene therapy by restoring neuronal cholesterol metabolism
Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-Salpêtrière
Institut du Cerveau et de la Moëlle épinière - INSERM U1127

FRANCE

ILE-DE-FRANCE
PARIS CEDEX 06

Funded by an IRDiRC memberThe effect of autophagy induction on the neuromuscular junction in ALS
Centre de Neurophysique, Physiologie et Pathologie - CNRS UMR 8119
Développement et pathologies des jonctions neuromusculaires

FRANCE

NOUVELLE AQUITAINE
BORDEAUX

Funded by an IRDiRC memberChloride-related inhibition in spinal motoneurons during the ALS disease progression in mouse model
Université Bordeaux 2 - Victor Ségalen
Institut de Neurosciences Cognitives et Intégratives - CNRS UMR 5287

FRANCE

NOUVELLE AQUITAINE
BORDEAUX

Funded by an IRDiRC memberThe P2X4 receptor: a key player in Amyotrophic Lateral Sclerosis and a biomarker
Université Bordeaux 2 - Victor Ségalen
Institut des Maladies Neurodégénératives (IMN) - CNRS UMR 5293

FRANCE

OCCITANIE
MONTPELLIER

Funded by an IRDiRC memberSpread and Toxicity of Pathogenic Factors in Amyotrophic Lateral Sclerosis
CHU de Montpellier - Hôpital Saint-Eloi
Institut des Neurosciences de Montpellier - INSERM U1051

FRANCE

OCCITANIE
MONTPELLIER

Funded by an IRDiRC memberAAV-mediated delivery of FGF as a therapeutic strategy for amyotrophic lateral sclerosis - FR
CHU de Montpellier - Hôpital Saint-Eloi
Institut des Neurosciences de Montpellier - INSERM U1051

FRANCE

OCCITANIE
MONTPELLIER

Funded by an IRDiRC memberInsights into the mode of action of flunarizine on microRNAs and/or targets in rare motor neurondiseases
Centre de recherche Inserm
Degeneration and plasticity of the locomotor system

FRANCE

OCCITANIE
MONTPELLIER

Funded by an IRDiRC memberDetermine how local translation of mRNA impacts neurodegenerative diseases
UMR5535 Institut de génétique moléculaire de Montpellier (IGMM)
Assemblage et Trafic de Ribonucléoprotéines

FRANCE

OCCITANIE
MONTPELLIER CEDEX 05

Funded by an IRDiRC memberDeciphering the beneficial effects of Sigma-1 receptor in amyotrophic lateral sclerosis
Mécanismes moléculaires dans les démences neurodégénératives (MMDN)
MMDN - Mécanismes Moléculaires dans les Démences Neurodégénératives

FRANCE

PROVENCE-ALPES-COTE D'AZUR
MARSEILLE

FRANCE

PROVENCE-ALPES-COTE D'AZUR
MARSEILLE

Funded by an IRDiRC memberG4C2 Repeat Sizing by Bionano Optical Mapping
Université de médecine Aix-Marseille Université
Institut des Neurosciences de la Timone

FRANCE

PROVENCE-ALPES-COTE D'AZUR
NICE

Funded by an IRDiRC memberIn vivo and in vitro direct lineage reprogramming of neuronal and somatic cells to corticospinal motor neurons
Université de Nice Sophia-Antipolis - Faculté des sciences
iBV - Institut de Biologie Valrose

GERMANY

Baden-Württemberg
ULM

Funded by an IRDiRC memberREPETOMICS: Genomic Instability of Expanded Repeats in HD and ALS/FTD -DE
Universitäts- und Rehabilitationskliniken Ulm (RKU)
Klinik für Neurologie

GERMANY

Bayern
MARTINSRIED/PLANEGG

Funded by an IRDiRC memberMAIV: Interdisciplinary consortium for the establishment of an in vitro disease model of ASL
BioMedical Center - BMC
Department of Physiological Genomics

GERMANY

Bayern
MÜNCHEN

Funded by an IRDiRC memberMAXOMOD: Multi-omic analysis of axono-synaptic degeneration in motoneuron disease - coordination, biomaterials and biomarkers -DE
Klinikum rechts der Isar der Technischen Universität München
Neurologische Klinik und Poliklinik

GERMANY

Berlin
BERLIN

Id-ALS-Study: Identification of genetic variants in ALS
Charité - Universitätsmedizin Berlin (CVK)
Klinik für Neurologie mit Experimenteller Neurologie (CVK)

GERMANY

Nordrhein-Westfalen
BONN

GERMANY

Nordrhein-Westfalen
BONN

Funded by an IRDiRC memberMAXOMOD: Multi-omic analysis of axono-synaptic degeneration in motoneuron disease - coordination, biomaterials and biomarkers -DE
Projektträger im Deutschen Zentrum für Luft- und Raumfahrt
ERA-Net for research programs on rare diseases - Germany

GERMANY

Nordrhein-Westfalen
ESSEN

GERMANY

Sachsen
DRESDEN

Deficits and potential for improvement in the psychosocial and palliative care of ALS patients in Germany
Universitätsklinikum Carl Gustav Carus an der TU Dresden
Klinik und Poliklinik für Neurologie

GERMANY

Schleswig-Holstein
LÜBECK

Uncovering novel causes and modifiers of amyotrophic lateral sclerosis by nuclear and mitochondrial genome sequencing
Universitätsklinikum Schleswig-Holstein - Campus Lübeck
Klinik für Neurologie

IRELAND

County Dublin
DUBLIN

EEG and TMS-based Biomarkers of ALS, MS and FTD
Trinity College Dublin
Department of Neurology - Trinity Biomedical Sciences Institute

IRELAND

County Dublin
DUBLIN

ISRAEL

ISRAEL
REHOVOT

Funded by an IRDiRC memberRigorous, integrated miRNA-DNA plasma biomarkers for amyotrophic lateral sclerosis
Arnold R. Meyer Institute of Biological Sciences, Weizmann Institute of Science
Department of Molecular Genetics

ISRAEL

ISRAEL
TEL AVIV

Funded by an IRDiRC memberALS-degeneration: The molecular basis for neurodegeneration and muscle atrophy in ALS - IL
University of Tel-Aviv
Dept. of Physiology and Pharmacology

ITALY

LAZIO
ROMA

Proposal for an integrated approach to rare diseases: a study between basic laboratory models and clinical epidemiology in amyotrophic lateral sclerosis (ALS)
ISS - Istituto Superiore di Sanità
Reparto Farmaci per la Salute del Bambino e della Donna - Dipartimento del Farmaco

ITALY

LAZIO
ROMA

Funded by an IRDiRC memberAmyotrophic Lateral Sclerosis (ALS) Registry in Latium Region
ISS - Istituto Superiore di Sanità
Centro Nazionale per la Prevenzione delle Malattie e la Promozione della Salute

ITALY

LAZIO
ROMA

Funded by an IRDiRC memberExosomal RNA for the diagnosis of ALS
ISS - Istituto Superiore di Sanità
Centro Nazionale per la Ricerca e la Valutazione preclinica e clinica dei Farmaci

ITALY

LAZIO
ROMA

Funded by an IRDiRC memberFollowing drug repurposing strategy: Preclinical assessment of new potential therapeutic target/drug in the SOD1G93A mouse model
ISS - Istituto Superiore di Sanità
Centro Nazionale per la Ricerca e la Valutazione preclinica e clinica dei Farmaci

ITALY

LAZIO
ROMA

Funded by an IRDiRC memberUncovering the function of HDAC4 in skeletal muscle
Sapienza Università di Roma - Sezione di Ricerca "Valdoni Lab"
Dipartimento di Scienze Anatomiche, Istologiche, Medico Legali e dell'Apparato Locomotore

ITALY

LOMBARDIA
MILANO

Modulating motor neuron vulnerability using the oculomotor restricted genes IGF-2 and SYT13 for ALS therapy
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
Dipartimento di Scienze Neurologiche

ITALY

LOMBARDIA
MILANO

Funded by an IRDiRC memberPreclinical studies aimed to develop target genes based therapies for the treatment of amyotrophic lateral sclerosis
Istituto di Ricerche Farmacologiche "Mario Negri"
Laboratorio di Neurobiologia Molecolare

ITALY

LOMBARDIA
PAVIA

ITALY

LOMBARDIA
PAVIA

Funded by an IRDiRC memberNovel therapeutic strategies for Spinal Muscular Atrophy: testing the efficacy of cell-permeable peptides in preclinical models
Istituti Clinici Scientifici Maugeri IRCCS
Laboratorio di Ricerca sulle malattie Neurodegenerative

ITALY

PIEMONTE
TORINO

Funded by an IRDiRC memberMutations in the MATR3 gene as a cause of amyotrophic lateral sclerosis (ALS)
Ospedale Molinette
Centro Regionale Esperto per la Sclerosi Laterale Amiotrofica e le malattie del motoneurone

ITALY

PUGLIA
BARI

Amyotrophic lateral sclerosis (SLA) and riboflavin responsive multiple Acyl-CoA dehydrogenase deficiency (RR-MADD)
Università degli Studi di Bari Aldo Moro
Laboratorio di Biochimica e Biologia Molecolare E.Quagliarello

NETHERLANDS

Gelderland
NIJMEGEN

PORTUGAL

SUL
LISBOA

Respiratory Rehabilitation in Amyotrophic Lateral Sclerosis: clinical and biochemical impact.
Faculdade de Medicina da Universidade de Lisboa
Unidade de Neuromusculares

PORTUGAL

SUL
OEIRAS

Mechanisms of SOD1 toxic aggregation in neurodegenerative processes
Instituto de Tecnologia Química e Biológica
Protein Biochemistry Folding and Stability

SPAIN

Aragón
ZARAGOZA

Funded by an IRDiRC memberEpigenetics in ALS-FTD spectrum: understanding the phenotypic variability and gaining new advances for personalized medicine
Centro de Investigación Biomédica de Aragón (CIBA)
Instituto de Investigación Sanitaria Aragón

SPAIN

Canarias
LAS PALMAS DE GRAN CANARIA

Funded by an IRDiRC memberUnderstanding TDP-43 central role in ALS and other TDP43 proteinopathies
Hospital Universitario de Gran Canaria Dr. Negrín
FIISC: Fundación Canaria Instituto de Investigación Sanitaria de Canarias

SPAIN

Cataluña
BARCELONA

Funded by an IRDiRC memberAdvancing the classification of frontotemporal dementia and amyotrophic lateral sclerosis with microstructural and functional neuroimaging, and blood-based biomarkers of neurodegeneration and neuroinflammation
IIB Sant Pau - Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

SPAIN

Cataluña
BARCELONA

Funded by an IRDiRC memberCharacterization of the transcriptomic and neuropathological profile of the postmortem tissue of amyotrophic lateral sclerosis patients carrying the C9orf72 hexanucleotide repeat expansion
IIB Sant Pau - Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

SPAIN

Cataluña
LLEIDA

Funded by an IRDiRC memberCell stress, lipid metabolism and RNA processing at the crossroad of ALS pathophysiology
Instituto de Investigación Biomédica de Lleida (IRBLLEIDA)
Instituto de Investigación Biomédica de Lleida - IRBLLEIDA

SPAIN

Comunidad Valenciana
VALENCIA

Funded by an IRDiRC memberRole of genetics, microbiota, and neurodegeneration and inflammation biomarkers in the development of precision medicine applied to ALS
Hospital Universitario y Politécnico La Fe
Fundación para la Investigación del Hospital Universitari La Fe

SPAIN

Madrid
MADRID

Funded by an IRDiRC memberEpigenetics in ALS-FTD spectrum: understanding the phenotypic variability and gaining new advances for personalized medicine
Instituto de Investigación Hospital 12 de Octubre
Fundación para la Investigación Biomédica del Hospital Universitario 12 de Octubre

SWEDEN

Region Skåne
LUND

Funded by an IRDiRC memberAAV-mediated delivery of FGF as a therapeutic strategy for amyotrophic lateral sclerosis
Lunds Universitet
Department of Experimental Medical Science

SWEDEN

Region Stockholm
STOCKHOLM

In vitro molecular mechanism of amyotrophic lateral sclerosis
Stockholm University
Department of Biochemistry and Biophysics

SWEDEN

Region Västerbotten
UMEÅ

SWEDEN

Region Västerbotten
UMEÅ

SWEDEN

Region Västerbotten
UMEÅ

SWEDEN

Region Västerbotten
UMEÅ

Studies of misfolded SOD1 in amyotrophic lateral sclerosis (ALS)
Umeå Universitet
Department of Medical Biosciences

SWITZERLAND

Suisse Alémanique
ZÜRICH

Exploring the molecular basis of disease heterogeneity in TDP-43 proteinopathies
Universität Zürich
Department of Quantitative Biomedizin

SWITZERLAND

Suisse Romande
LAUSANNE

Funded by an IRDiRC memberAAV-mediated delivery of FGF as a therapeutic strategy for amyotrophic lateral sclerosis - CH
EPFL - Ecole Polytechnique Fédérale de Lausanne
Bertarelli Platform for Gene Therapy

UNITED KINGDOM

Greater London
LONDON

Investigating neuronal RNA localisation and translational deficits as gain of function mechanisms in ALS.
UCL Institute of Neurology, University College London,
Clinical Neurosciences

UNITED KINGDOM

Greater London
LONDON

UNITED KINGDOM

Oxfordshire
OXFORD

Antisense Oligonucleotide Therapy for Neuromuscular Disease
University of Oxford
Department of Physiology, Anatomy and Genetics

UNITED STATES

Illinois
CHICAGO

Funded by an IRDiRC memberStudying nucleocytoplasmic imbalances to design new therapeutic strategies for amyotrophic lateral sclerosis
Northwestern University Feinberg School of Medicine
Department of pathology

UNITED STATES

Massachusetts
BOSTON

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberModeling the progression of sod1-linked motor neuron disease
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberExtrinsic mechanisms governing injury-induced axon degeneration
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberInvestigating disease mechanisms in c9orf72-linked als/ftd
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberP97 inhibitors for treatment of ibmpfd/als
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberMuscle tregs in health and disease
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberAmpk; metabolism and als
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberEpigenetic editing of mutant c9orf72
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberInvestigating a2-chimaerin-dependent motor neuron protection in als
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberInvestigation of als caused by mutant chchd10
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberMechanisms of hipk2 in neurodegeneration
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberNucleocytoplasmic transport and nuclear pore disruption in als/ftd
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberRole of c9orf72 in neurodegeneration
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberRole of oligodendroglia in the pathogenesis of als
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberStudy on hnrnpa1 pathobiology in als
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberDetermination of cell death pathways activated in als
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberOligodendroglial dysfunction in c9orf72 als and ftd
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberStudy on neurodegeneration using tdp-43 transgenic rats
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberFg-nucleoporins and nuclear transport disruption in c9orf72-als/ftd
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberMechanisms of motor neuron disease
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberNad metabolsim and mitochondrial dysfunction in als models
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberRegulation of glutamate transport in astrocyte subtypes and in als
Institution: Information not provided - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

UNITED STATES

Washington
ADDRESS: NOT PROVIDED - US

Funded by an IRDiRC memberGenetic control of phrenic motor neuron development and maintenance
Institution: Information not provided - US

FRANCE

AUVERGNE-RHONE-ALPES
LYON

Funded by an IRDiRC memberThe extracellular matrix collagen XV as a new player of motor axon development and regeneration: a functional study using zebrafish
Institut de Génomique Fonctionnelle de Lyon
Matrix Biology and Pathology, Managemant

SPAIN

Asturias
OVIEDO

Funded by an IRDiRC memberThe emergent pathogenic role for the intermediate CAG repeats in the HTT gene: from the neuropathological evidences to the molecular findings
Fundación para la Investigación Biosanitaria del Principado de Asturias
FINBA: Fundación para la Investigación Biosanitaria del Principado de Asturias

SPAIN

Cataluña
BARCELONA

Advanced genomics and lipidomics for identifying novel causes of inherited movement disorders
Instituto de Química Avanzada de Cataluña
Unidad de Investigación en Moléculas Bioactivas

SPAIN

Cataluña
L'HOSPITALET DE LLOBREGAT

Advanced genomics and lipidomics for identifying novel causes of inherited movement disorders
IDIBELL - Instituto de Investigación Biomédica de Bellvitge
Laboratorio de Enfermedades Neurometabólicas

SPAIN

País Vasco
SAN SEBASTIÁN

Advanced genomics and lipidomics for identifying novel causes of inherited movement disorders
Instituto de Investigación Sanitaria Biodonostia
Área de Neurociencias

BELGIUM

ANTWERPEN
ANTWERPEN

Funded by an IRDiRC memberA preclinical study to treat neuromuscular diseases caused by mutations in the small heat shock protein HSPB8
University of Antwerp - UA, Campus Drie Eiken
Peripheral Neuropathy Research Group

CANADA

Ontario
OTTAWA, ONTARIO

FRANCE

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR

FRANCE

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR

FRANCE

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR

FRANCE

AUVERGNE-RHONE-ALPES
GRENOBLE

Funded by an IRDiRC memberEarly identification of respiratory exacerbations using NIV device monitoring in slowly progressive neuromuscular disorders
CHU Grenoble Alpes - Site Nord - Hôpital Couple Enfant
Laboratoire EFCR/Pneumologie

FRANCE

AUVERGNE-RHONE-ALPES
LYON

Funded by an IRDiRC memberInterplay between cell metabolism and alternative splicing
ENS - Ecole normale supérieure de Lyon
Laboratoire de biologie et modélisation de la cellule - UMR5239

FRANCE

AUVERGNE-RHONE-ALPES
LYON

Funded by an IRDiRC memberAmino acid metabolism and alternative splicing
ENS - Ecole normale supérieure de Lyon
Laboratoire de biologie et modélisation de la cellule - UMR5239

FRANCE

ILE-DE-FRANCE
CRÉTEIL

FRANCE

ILE-DE-FRANCE
CRÉTEIL

Funded by an IRDiRC memberAn integrated translational program for neuromuscular disorders
Faculté de Médecine de Créteil
Equipe "Biologie du système neuromusculaire"

FRANCE

ILE-DE-FRANCE
CRÉTEIL

Funded by an IRDiRC memberAn integrated translational program for neuromuscular disorders
Hôpitaux Universitaires Henri Mondor
Centre expert de maladie neuro-musculaire

FRANCE

ILE-DE-FRANCE
GARCHES

Funded by an IRDiRC memberPatient-ventilator asynchrony in neuromuscular disease: real life evaluation using devices softwares
CHU Paris IdF Ouest - Hôpital Raymond Poincaré
Service de Physiologie-Explorations Fonctionnelles - Consultations Troubles du sommeil

FRANCE

ILE-DE-FRANCE
GARCHES

Funded by an IRDiRC memberEarly identification of respiratory exacerbations using NIV device monitoring in slowly progressive neuromuscular disorders
CHU Paris IdF Ouest - Hôpital Raymond Poincaré
Service de Physiologie-Explorations Fonctionnelles - Consultations Troubles du sommeil

FRANCE

ILE-DE-FRANCE
PARIS

FRANCE

ILE-DE-FRANCE
PARIS

Funded by an IRDiRC membersPAM: Developing peptide-based drugs to target ataxin-2 in neuromuscular disease - FR
Institut du Cerveau et de la Moelle épinière (ICM) - Hôpital Pitié-Salpêtrière
Equipe "Traitement de la sclérose latérale amyotrophique : de la génétique au poisson zèbre"

FRANCE

PAYS DE LA LOIRE
NANTES

FRANCE

PROVENCE-ALPES-COTE D'AZUR
MARSEILLE

Funded by an IRDiRC memberModelisation and Therapeutic Approaches for Rare Diseases
Université de médecine Aix-Marseille Université
Centre de Génétique de Marseille (Marseille Medical Genetics - MMG)

FRANCE

PROVENCE-ALPES-COTE D'AZUR
MARSEILLE

Funded by an IRDiRC memberA quantitative MRI platform for simultaneous and automatic quantification of fat infiltration and T2 relaxation times in neuromuscular disorders - FR
Université de médecine Aix-Marseille Université
Centre de Résonance Magnétique Biologique et Médicale

ITALY

LAZIO
ROMA

Funded by an IRDiRC memberDiverse rare diseases caused by functional dysregulation of Rho GTPase-related proteins
ISS - Istituto Superiore di Sanità
Centro Nazionale Malattie Rare

ITALY

LAZIO
ROMA

Funded by an IRDiRC memberCellular network driving neuromuscular junction stability
Sapienza Università di Roma
Università degli Studi di Roma "La Sapienza"

NETHERLANDS

Zuid-Holland
LEIDEN

Funded by an IRDiRC memberUnderstanding histopathological alterations in neuromuscular disorders by spatial transcriptomics
LUMC - Leids Universitair Medisch Centrum
Afdeling Humane Genetica

NORWAY

Østlandet
OSLO

Mekanisk hostestøtte for barn med nevromuskulær sykdom og svak hoste
Oslo University Hospital, Ullevaal
Oslo University Hospital, Ullevål

SPAIN

Cataluña
BARCELONA

SPAIN

Cataluña
BARCELONA

Igenco: In-Depth genomics and cross-omics analysis for undiagnosed rare diseases on a user-friendly collaborative platform
ISGlobal - Instituto de Salud Global de Barcelona
Programa de investigación en Enfermedades no transmisibles y medio ambiente

UNITED KINGDOM

Tyne & Wear
NEWCASTLE UPON TYNE

UNITED STATES

California
PALO ALTO

Funded by an IRDiRC membersPAM: Developing peptide-based drugs to target ataxin-2 in neuromuscular disease - US
Stanford University School of Medicine
Department of Genetics

CANADA

Colombie-Britannique
VICTORIA

CANADA

Ontario
TORONTO

SPAIN

Cataluña
BARCELONA

Catalan Interhospital Network of Genetic Variants to improve genetic diagnosis in rare diseases
Centro de Regulación Genómica
Archivo europeo de genomas y fenomas del CRG

SPAIN

Cataluña
BARCELONA

SPAIN

Cataluña
BARCELONA

SPAIN

Cataluña
BARCELONA

SPAIN

Cataluña
ESPLUGUES DE LLOBREGAT

Federated network for functional genomics of undiagnosed and rare diseases, RareFunction
Fundació Sant Joan de Déu - Institut de Recerca Sant Joan de Déu
Grupo de investigación en Neurogenética y Medicina Molecular

SPAIN

Cataluña
ESPLUGUES DE LLOBREGAT

SPAIN

Cataluña
L'HOSPITALET DE LLOBREGAT

Catalan Interhospital Network of Genetic Variants to improve genetic diagnosis in rare diseases
Hospital Universitari de Bellvitge
Unidad de Genética Molecular

SPAIN

Madrid
MADRID

Funded by an IRDiRC memberIdentification of new genes causing rare diseases in pediatric patients, searching of genetic pharmacological targets, and drugs discovery, the steps for a personalized medicine
Instituto de Investigación Hospital 12 de Octubre
Grupo de investigación en enfermedades raras, mitocondriales y neuromusculares

Multicentric Research projects