Orphanet: Clinical Signs and Symptoms

Clinical Signs and Symptoms

ORPHA:328 Congenital factor X deficiency

The phenotypic description of this disease is based on an analysis of the biomedical literature and uses the terms of the Human Phenotype Ontology (HPO). Phenotypic abnormalities are presented by order of frequency of occurrence in the patient population, then by alphabetical order inside each frequency group.

Diagnostic criterion *

Reduced factor X activity HP:0008321

* Phenotypic abnormalities noted as « diagnostic criterion » are those included in established sets of criteria to establish the diagnosis of a particular disease having been published in a peer-reviewed journal.

Clinical signs and symptoms

Always present

Prolonged prothrombin time HP:0008151
Reduced factor X activity HP:0008321

Very frequent

Prolonged bleeding after dental extraction HP:0006298
Prolonged bleeding after surgery HP:0004846

Frequent

Epistaxis HP:0000421
Gingival bleeding HP:0000225

Occasional

Abnormal umbilical stump bleeding HP:0011884
Antepartum hemorrhage HP:0025328
Bruising susceptibility HP:0000978
Gastrointestinal hemorrhage HP:0002239
Hematuria HP:0000790
Intramuscular hematoma HP:0012233
Joint hemorrhage HP:0005261
Menorrhagia HP:0000132
Oral cavity bleeding HP:0030140
Post-partum hemorrhage HP:0011891
Spontaneous hematomas HP:0007420

Rare

Hemoperitoneum HP:0011854
Subarachnoid hemorrhage HP:0002138

Additional information

Further information

Specialised Social Services

Eurordis directory

Warning

The information provided is based on published scientific articles.

The information provided is estimated for the entire population of patients in routine care. Some phenotypic abnormalities reported here may occur individually with a variable temporality or severity, while others, not listed, may still be encountered. Phenotypic annotations are not yet available for all rare diseases; the annotation process is ongoing.

The information contained in Orphanet is regularly updated. It is possible that discoveries have been made since the last update and have not yet been incorporated.

Professionals are encouraged to always consult the latest scientific publications before making a decision based on the information provided. The information contained in Orphanet is not intended to replace the services of a healthcare professional. Orphanet cannot be held responsible for the deleterious, truncated or erroneous use of any information found in the Orphanet database.