Orphanet: Cold agglutinin disease

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Cold agglutinin disease

Disease definition

Cold agglutinin disease is a type of autoimmune hemolytic anemia (see this term) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C).


Classification level: Disorder
  • Synonym(s):
    • CAD
    • CAS
    • Chronic cold agglutinin disease
    • Cold agglutinin syndrome
  • Prevalence: 1-9 / 1 000 000
  • Inheritance: Multigenic/multifactorial 
  • Age of onset: Adult
  • ICD-10: D59.1
  • OMIM: -
  • UMLS: C0175816
  • MeSH: -
  • GARD: 6130
  • MedDRA: -

Detailed information

Article for general public


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