Orphanet: Search a disease

Search for a rare disease

* (*) mandatory field

Other search option(s)

Suggest an update

(*) Required fields.


Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. For all other comments, please send your remarks via contact us. Only comments written in English can be processed.

Captcha image

Hereditary motor and sensory neuropathy type 5

Disease definition

Hereditary motor and sensory neuropathy type 5 is a rare axonal hereditary motor and sensory neuropathy characterized by slowly progressive distal muscle weakness and atrophy with or without sensory loss resulting in difficulty in walking, foot drop and pes cavus, that may be associated with pyramidal signs (extensor plantar responses, mild increase in tone, brisk tendon reflexes), muscle cramps, pain and spasticity.


Classification level: Disorder
  • Synonym(s):
    • Charcot-Marie-Tooth disease-pyramidal features syndrome
    • HMSN 5
    • HMSN V
    • Hereditary motor and sensory neuropathy type V
  • Prevalence: -
  • Inheritance: -
  • Age of onset: Adult
  • ICD-10: G60.0
  • OMIM: 600361
  • UMLS: -
  • MeSH: -
  • GARD: 9208
  • MedDRA: -

Detailed information


The documents contained in this web site are presented for information purposes only. The material is in no way intended to replace professional medical care by a qualified specialist and should not be used as a basis for diagnosis or treatment.