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Paroxysmal nocturnal hemoglobinuria

Disease definition

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder characterized by corpuscular hemolytic anemia, bone marrow failure and frequent thrombotic events.

ORPHA:447

Classification level: Disorder
  • Synonym(s):
    • Marchiafava-Micheli disease
    • PNH
  • Prevalence: 1-9 / 100 000
  • Inheritance: -
  • Age of onset: All ages
  • ICD-10: D59.5
  • OMIM: 300818  615399
  • UMLS: C0024790
  • MeSH: D006457
  • GARD: 7337
  • MedDRA: 10034042

Detailed information

Article for general public

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