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Susceptibility to viral and mycobacterial infections due to STAT1 deficiency

Disease definition

Susceptibility to viral and mycobacterial infections is a rare, genetic, primary immunodeficiency due to a defect in innate immunity disorder characterized by impaired intracellular signaling from both type I and type II interferons, leading to early-onset, severe, life-threatening intracellular bacterial (typically mycobacteria) and viral (mainly herpes viruses) infections.

ORPHA:391311

Classification level: Disorder
  • Synonym(s):
    • Predisposition to severe viral infection due to STAT1 deficiency
    • STAT1 deficiency
  • Prevalence: -
  • Inheritance: Autosomal recessive 
  • Age of onset: -
  • ICD-10: D84.8
  • OMIM: 613796
  • UMLS: -
  • MeSH: -
  • GARD: -
  • MedDRA: -
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