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Hereditary angioedema with normal C1Inh
Disease definition
A rare hereditary angioedema characterized by potentially life-threatening episodes of subcutaneous and/or submucosal edema without urticaria and with normal levels and function of C1 esterase inhibitor. Patients present with prolonged attacks which last for approximately two to five days and may include nonpitting edema of the skin, severe abdominal symptoms such as pain and swelling, and/or respiratory distress due to upper respiratory airways involvement. Affected locations and frequency of attacks differ slightly between subtypes. Estrogen-containing oral contraceptives and pregnancy are precipitating factors, especially in patients with a factor XII mutation.
ORPHA:528647
Classification level: Disorder- Synonym(s):
- HAE with normal C1 inhibitor
- HAE with normal C1Inh
- Hereditary angioedema with normal C1 inhibitor
- Hereditary angioneurotic edema with normal C1 inhibitor
- Hereditary angioneurotic edema with normal C1Inh
- Prevalence: -
- Inheritance: Not applicable
- Age of onset: -
- ICD-10: T78.3
- ICD-11: 4A00.14
- OMIM: -
- UMLS: C1960459
- MeSH: -
- GARD: -
- MedDRA: -
A summary on this disease is available in Español (2021) Français (2021) Nederlands (2021)
Detailed information
Guidelines
- Emergency guidelines
- Français (2021, pdf) - Orphanet Urgences
- Clinical practice guidelines
- Français (2021) - PNDS
produced/endorsed by ERN(s) produced/endorsed by FSMR(s)Additional information
Further information on this disease
Patient-centred resources for this disease
Research activities on this disease
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