Orphanet: Langerhans cell histiocytosis

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Langerhans cell histiocytosis

Disease definition

Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues.


Classification level: Disorder
  • Synonym(s):
    • Histiocytosis X
    • Langerhans cell granulomatosis
  • Prevalence: 1-9 / 100 000
  • Inheritance: Unknown 
  • Age of onset: All ages
  • ICD-10: C96.0  C96.5  C96.6
  • OMIM: 604856
  • UMLS: C0019621
  • MeSH: D006646
  • GARD: 6858
  • MedDRA: 10069698

Detailed information

Article for general public

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