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Aplasia cutis congenita-intestinal lymphangiectasia syndrome

Disease definition

An extremely rare association syndrome, described in only two brothers to date (one of which died at 2 months of age), characterized by aplasia cutis congenita of the vertex and generalized edema (as well as hypoproteinemia and lymphopenia) due to intestinal lymphangiectasia. There have been no further descriptions in the literature since 1985.

ORPHA:1116

Classification level: Disorder
  • Synonym(s):
    • Autosomal recessive aplasia cutis
    • Bronspiegel-Zelnick syndrome
  • Prevalence: <1 / 1 000 000
  • Inheritance: Autosomal recessive 
  • Age of onset: Neonatal
  • ICD-10: -
  • OMIM: 207731
  • UMLS: C1859753
  • MeSH: C537788
  • GARD: 753
  • MedDRA: -
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