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Acute myeloblastic leukemia with maturation

Disease definition

A rare, acute myeloid leukemia characterized by evidence of granulocytic maturation and more than 20% of blast cells in the bone marrow and/or peripheral blood. The maturing non-blast granulocytic cells account for greater than or equal to 10% and monocytic cells less than or equal to 20% of the bone marrow cells. Various degrees of anemia, thrombocytopenia, or pancytopenia are present. Frequent clinical manifestations include fatigue, fever, bleeding disorders, and organomegaly, especially hepatosplenomegaly.

ORPHA:98834

Classification level: Disorder
  • Synonym(s):
    • AML M2
    • Acute myeloblastic leukemia M2
  • Prevalence: -
  • Inheritance: -
  • Age of onset: All ages
  • ICD-10: C92.0
  • OMIM: -
  • UMLS: C1879321
  • MeSH: -
  • GARD: 527
  • MedDRA: -

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