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Ensayo(s) clínico(s) nacional(es)

AUVERGNE-RHONE-ALPES
GRENOBLE
Molecular and Cellular Print Medical Device Validation in Adult Glioma Tumors (Phase I) - FR
Centre Hospitalier Universitaire Grenoble Alpes

Baden-Württemberg
HEIDELBERG

INFORM2 NivEnt: exploratory multinational phase I/II combination study of Nivolumab and Entinostat in children and adolescents with refractory high-risk malignancies
Deutsches Krebsforschungszentrum
Klinische Kooperationseinheit Pädiatrische Onkologie

Bayern
AUGSBURG
SIOP-LGG-2004: Radiation therapy or combination Chemotherapy in treating Patients with clinically or radiologically progressive Low-Grade Gliomas
Universitätsklinikum Augsburg
Schwäbisches Kinderkrebszentrum

Bayern
REGENSBURG

INFORM2 NivEnt: exploratory multinational phase I/II combination study of Nivolumab and Entinostat in children and adolescents with refractory high-risk malignancies
Universitätsklinikum Regensburg
Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation

Nordrhein-Westfalen
ESSEN

INFORM2 NivEnt: exploratory multinational phase I/II combination study of Nivolumab and Entinostat in children and adolescents with refractory high-risk malignancies
Universitätsklinikum Essen
Klinik für Kinderheilkunde III - Abteilung für pädiatrische Hämatologie und Onkologie

NIEDERÖSTERREICH
ST. PÖLTEN
LAHENE Study: Perioperative Levetiracetam for seizure prophylaxis in brain tumor patients. Prospective evaluation of side effects and efficacy (phase 2)
Universitätsklinikum St. Pölten
Karl Landsteiner Institut für klinische Neurologie und Neuropsychologie

WIEN
WIEN
A Phase II, Open-label, Study in Subjects With BRAF V600E-Mutated Rare Cancers With Several Histologies to Investigate the Clinical Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib - AT
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Onkologie

WIEN
WIEN

VINILO: Phase I-II Study of Vinblastine in Combination With Nilotinib in Children, Adolescents, and Young Adults With Refractory or Recurrent Low-Grade Glioma - AT
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Neonatologie, Pädiatrische Intensivmedizin und Neuropädiatrie

WIEN
WIEN
Phase I/II Open Label, Dose Escalation Trial to Determine the MTD, Safety, PK and Efficacy of Afatinib Monotherapy in Children Aged 1 Year to <18 Years With Recurrent/Refractory Neuroectodermal Tumours, Rhabdomyosarcoma and/or Other Solid Tumours With Known ErbB Pathway Deregulation Regardless of Tumour Histology - AT
St. Anna Kinderspital
Zentrum für Kinder- und Jugendheilkunde

WIEN
WIEN

INFORM2 NivEnt: Exploratory Multinational Phase I/II Combination Study of Nivolumab and Entinostat in Children and Adolescents With Refractory High-risk Malignancies - AT
St. Anna Kinderspital
Zentrum für Kinder- und Jugendheilkunde

Cataluña
BARCELONA
Estudio de fase II, abierto, en sujetos con cánceres raros de diversas histologías con la mutación BRAF V600E para investigar la eficacia clínica y la seguridad del tratamiento combinado con dabrafenib y trametinib
Hospital Universitari Vall d'Hebron
Servicio de Oncología Médica

Cataluña
ESPLUGUES DE LLOBREGAT

VINILO: Estudio fase I-II de vinblastina en combinación con nilotinib en niños, adolescentes, y adultos jóvenes con glioma de bajo grado refractario o recurrente
Hospital Sant Joan de Déu Barcelona
Servicio de Oncología y Hematología

Madrid
MADRID
Estudio de fase II, abierto, en sujetos con cánceres raros de diversas histologías con la mutación BRAF V600E para investigar la eficacia clínica y la seguridad del tratamiento combinado con dabrafenib y trametinib
Hospital Universitario 12 de Octubre
Servicio de Oncología Médica

Navarra
PAMPLONA
Estudio de fase II, abierto, en sujetos con cánceres raros de diversas histologías con la mutación BRAF V600E para investigar la eficacia clínica y la seguridad del tratamiento combinado con dabrafenib y trametinib
Clínica Universidad de Navarra
Servicio de Oncología Médica

California
LA JOLLA

A Phase II Trial of Poly-ICLC in the Management of Recurrent Pediatric Low Grade Gliomas - US
University of California San Diego
University of California, San Diego

HAUTS-DE-FRANCE
LILLE

Cilengitide (EMD121974) in combination with irradiation in children and young adults with newly diagnosed diffuse intrinsic pontine glioma : Phase I study
CLCC Oscar Lambret
Unité d'oncologie pédiatrique

HAUTS-DE-FRANCE
LILLE

OVIMA : Phase II Trial of Oral Vinorelbine in Children With Recurrent or Progressive Unresectable Low-Grade Glioma
CLCC Oscar Lambret
Unité d'oncologie pédiatrique

ILE-DE-FRANCE
PARIS

A Study Evaluating Dexamfetamine Sulphate in Patients With Glioma Suffering From Severe Asthenia. A Phase III Double-blind Randomized Placebo-controlled Trial
APHP.Sorbonne Université, Hôpital de la Pitié-Salpêtrière
Unité Fonctionnelle Epilepsie

ILE-DE-FRANCE
VILLEJUIF

BIOMEDE: Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication (Phase II) - FR
CLCC Institut Gustave Roussy
Département de Cancérologie de l'enfant et de l'adolescent

ILE-DE-FRANCE
VILLEJUIF

VINILO: Phase I-II Study of Vinblastine in Combination With Nilotinib in Children, Adolescents, and Young Adults With Refractory or Recurrent Low-Grade Glioma - FR
CLCC Institut Gustave Roussy
Département de Cancérologie de l'enfant et de l'adolescent

LOMBARDIA
MILANO

Phase II, open label, monocentric, uncontrolled, non randomized clinical trial on Sodium Fluorescein for Surgery of High Grade Gliomas
Fondazione IRCCS Istituto Neurologico "Carlo Besta"
UOC Neurochirurgia 2 - Neurochirurgia Vascolare

Warszawa
WARSAW

Cooperative Multicenter Study for Children and Adolescents With Low Grade Glioma - PL
Instytut "Pomnik-Centrum Zdrowia Dziecka"
Klinika Onkologii IP-CZD

NORTE
PORTO

Cooperative Multicenter Study for Children and Adolescents With Low Grade Glioma - PT
Centro Hospitalar de S. João, EPE
Unidade de Hematologia e Oncologia Pediátrica

West Midlands
BIRMINGHAM

PARC: Phase I/II Study Evaluating the Safety and Activity of Pegylated Recombinant Human Arginase (BCT-100) in Relapsed/Refractory Cancers of Children and Young Adults -GB
University of Birmingham
University of Birmingham HQ

West Yorkshire
LEEDS

CNS 2004 03: Cooperative Multicentre Study For Children And Adolescents With Low Grade Glioma (Phase III) (SIOP-LGG 2004) - UK
St James's University Hospital
Regional Paediatric Oncology Unit

Baden-Württemberg
HEIDELBERG
CATNON (EORTC 26053-22054) - Phase III trial on concurrent and adjuvant Temozolomide chemotherapy in non-1p/19q deleted Anaplastic Glioma - DE
Neurologische Universitätsklinik Heidelberg
Abteilung für Neuroonkologie

Baden-Württemberg
HEIDELBERG
EORTC 26052-22053 (RTOG 0525) : Phase III trial comparing conventional adjuvant Temozolomide with dose-intensive Temozolomide in patients with newly diagnosed Glioblastoma
Neurologische Universitätsklinik Heidelberg
Abteilung für Neuroonkologie

Baden-Württemberg
HEIDELBERG

EORTC 26081-22086 (CODEL): Phase III intergroup study of Radiotherapy versus Temozolomide alone versus Radiotherapy with concomitant and adjuvant Temozolomide for patients with 1p/19q codeleted Anaplastic Glioma - DE
Neurologische Universitätsklinik Heidelberg
Abteilung für Neuroonkologie

Baden-Württemberg
HEIDELBERG

TAVAREC (EORTC 26091) - Randomized trial assessing the significance of Bevacizumab in recurrent Grade II and Grade III Glioma (Phase II) - DE
Neurologische Universitätsklinik Heidelberg
Abteilung für Neuroonkologie

Baden-Württemberg
HEIDELBERG
EORTC 26062-22061: A randomized phase III study of Temozolomide and short-course radiation versus short-course radiation alone in the treatment of newly diagnosed glioblastoma multiforme in elderly patients - DE
Neurologische Universitätsklinik Heidelberg
Abteilung für Neuroonkologie

Baden-Württemberg
HEIDELBERG

EORTC 26101: Randomized phase II trial exploring the sequence of Bevacizumab and Lomustine in patients with first recurrence of a Glioblastoma
Neurologische Universitätsklinik Heidelberg
Abteilung für Neuroonkologie

Baden-Württemberg
HEIDELBERG
A Phase II, multicenter, randomized, double-blind study of LY2157299 monohydrate monotherapy or LY2157299 monohydrate Plus Lomustine therapy compared to Lomustine monotherapy in patients with recurrent Glioblastoma - DE
Neurologische Universitätsklinik Heidelberg
Abteilung für Neuroonkologie

Baden-Württemberg
HEIDELBERG

ABT-414 alone or ABT-414 plus Temozolomide versus Lomustine or Temozolomide for recurrent Glioblastoma: a randomized phase II study of the EORTC Brain Tumor Group - DE
Neurologische Universitätsklinik Heidelberg
Abteilung für Neuroonkologie

Baden-Württemberg
HEIDELBERG

Intellance 1: A Randomized, Placebo Controlled Phase 2b/3 Study of ABT-414 With Concurrent Chemoradiation and Adjuvant Temozolomide in Subjects With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification - DE
Neurologische Universitätsklinik Heidelberg
Abteilung für Neuroonkologie

Baden-Württemberg
HEIDELBERG


NOA-20/Improvement of functional outcome for patients with newly diagnosed grade II or III glioma with co-deletion of 1p/19q - IMPROVE CODEL
Neurologische Universitätsklinik Heidelberg
Abteilung für Neuroonkologie

Baden-Württemberg
HEIDELBERG

An open-label, Phase I/II multicenter clinical trial of VXM01 in combination with avelumab in patients with progressive glioblastoma following standard treatment with or without second surgery -DE-
Neurologische Universitätsklinik Heidelberg
Abteilung für Neuroonkologie

Baden-Württemberg
HEIDELBERG
GERAS: Effect of Timing of Tumor-Treating Fields Plus Short-Course Radiation in Elderly Patients With Glioblastoma
Neurologische Universitätsklinik Heidelberg
Klinik für Radioonkologie und Strahlentherapie

Baden-Württemberg
HEIDELBERG
Phase 3b Study for Management of Ocular Side Effects in Subjects With EGFR-amplified Glioblastoma Receiving Depatuxizumab Mafodotin (ABT-414) -DE-
Universitätsklinikum Heidelberg

Baden-Württemberg
TÜBINGEN

Impact of iMRI on the Extent of Resection in Patients With Newly Diagnosed Glioblastomas - A Prospective Multicenter Parallel Group Clinical Trial - DE
CCC Tübingen-Stuttgart
Comprehensive Cancer Center Tübingen-Stuttgart

Baden-Württemberg
TÜBINGEN
Phase 3b Study for Management of Ocular Side Effects in Subjects With EGFR-amplified Glioblastoma Receiving Depatuxizumab Mafodotin (ABT-414) -DE-
Universitätsklinikum Tübingen

Baden-Württemberg
TÜBINGEN

CheckMate 498: A Randomized Phase 3 Open Label Study of Nivolumab vs Temozolomide Each in Combination with Radiation Therapy in Newly Diagnosed Adult Subjects with Unmethylated MGMT (tumor 06-methylguanine DNA methyltransferase) Glioblastoma - DE
Zentrum für Neurologie und Klinik für Neurochirurgie
Zentrum für Neuroonkologie (ZNO)

Baden-Württemberg
TÜBINGEN

CheckMate 548: A Randomized Phase 3 Single Blind Study of Temozolomide Plus Radiation Therapy Combined With Nivolumab or Placebo in Newly Diagnosed Adult Subjects With MGMT-Methylated (Tumor O6-methylguanine DNA Methyltransferase) Glioblastoma - DE
Zentrum für Neurologie und Klinik für Neurochirurgie
Zentrum für Neuroonkologie (ZNO)

Bayern
ERLANGEN

CheckMate 498: A Randomized Phase 3 Open Label Study of Nivolumab vs Temozolomide Each in Combination with Radiation Therapy in Newly Diagnosed Adult Subjects with Unmethylated MGMT (tumor 06-methylguanine DNA methyltransferase) Glioblastoma - DE
Universitätsklinikum Erlangen - Kopfkliniken
Neurologische Klinik

Bayern
MÜNCHEN

GlioCave/NOA17: Adjuvant Stereotactic Fractionated Radiotherapy to the Resection Cavity in Recurrent Glioblastoma (Phase 2) - DE
Klinikum rechts der Isar der Technischen Universität München
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie

Bayern
MÜNCHEN
Evaluation of the Feasibility of PD L 506 for Stereotactic Interstitial Photodynamic Therapy (iPDT) in Adult Patients With Newly Diagnosed Supratentorial IDH Wild-type Glioblastoma
LMU Klinikum der Universität München - Campus Großhadern
Neurochirurgische Klinik und Poliklinik

Bayern
REGENSBURG
Phase 3b Study for Management of Ocular Side Effects in Subjects With EGFR-amplified Glioblastoma Receiving Depatuxizumab Mafodotin (ABT-414) -DE-
Universität Regensburg

Berlin
ADDRESS: NOT PROVIDED - DE
A Phase I/II Multi Centre Single Arm, Open Label Study of Intraparenchymal Therapy With Irinotecan Hydrochloride Drug-eluting Beads (CM-BC2) as a Adjunct Therapy to Best Standard of Care in Patients With Recurrent, Surgically Resectable High Grade Glioma -DE-
Institution: Information not provided - DE

Berlin
BERLIN

The C-GBM Study: Prospective controlled phase II trial of Cabazitaxel in patients with Temozolomide refractory Glioblastoma Multiforme - DE
Charité - Universitätsmedizin Berlin (CVK)
Medizinische Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie

Hamburg
HAMBURG
Phase 3b Study for Management of Ocular Side Effects in Subjects With EGFR-amplified Glioblastoma Receiving Depatuxizumab Mafodotin (ABT-414) -DE-
Hubertus Wald Tumorzentrum/ Universitäres Cancer Center (UCCH)
Comprehensive Cancer Center (CCC) Hamburg

Hamburg
HAMBURG

OSAG101-BSA05: Phase-III study of standard radiotherapy plus concomitant and adjuvant OSAG 101 (Theraloc®) plus temozolomide vs. standard radiotherapy plus concomitant and adjuvant temozolomide in patient with newly diagnosed, histological confirmed glioblastoma multiforme grade IV
UKE - Universitätsklinikum Hamburg-Eppendorf
Klinik und Poliklinik für Neurochirurgie

Hamburg
HAMBURG

A prospective, multicenter phase III trial of NovoTTF-100A together with Temozolomide compared to Temozolomide alone in patients with newly diagnosed Glioblastoma Multiforme (GBM)
UKE - Universitätsklinikum Hamburg-Eppendorf
Klinik und Poliklinik für Neurochirurgie

Niedersachsen
GÖTTINGEN

HIT-HGG-2007: International cooperative phase II trials of the HIT-HGG study group for the treatment of high grade Glioma, Diffuse Intrinsic Pontine Glioma, and Gliomatosis Cerebri in children and adolescents 3 years and older up to 18 years
Universitätsmedizin Göttingen
Klinik für Kinder- und Jugendmedizin

Niedersachsen
GÖTTINGEN
HIT-HGG-CilMetro: Cilengitide and Metronomic Temozolomide for relapsed or refractory high grade Gliomas or Diffuse Intrinsic Pontine Gliomas in children and adolescents - Prospective non- randomised phase II study
Universitätsmedizin Göttingen
Klinik für Kinder- und Jugendmedizin

Niedersachsen
GÖTTINGEN

Autologous Dendritic Cells and Metronomic Cyclophosphamide for Relapsed High-Grade Gliomas in Children and Adolescents
Universitätsmedizin Göttingen
Klinik für Kinder- und Jugendmedizin

Nordrhein-Westfalen
BONN

GLORIA: Single-arm, Dose-Escalation, Phase 1/2 Study of Olaptesed Pegol (NOX-A12) in Combination with Irradiation in Inoperable or Partially Resected First-line Glioblastoma Patients with Unmethylated MGMT Promoter
Universitätsklinikum Bonn (AöR)
Klinik und Poliklinik für Neurologie

Nordrhein-Westfalen
DÜSSELDORF


Phase II trial of vaccination with lysate-loaded, mature dendritic cells integrated into standard radiochemotherapy in newly diagnosed glioblastoma -DE-
Universitätsklinikum Düsseldorf
Klinik für Neurochirurgie

Nordrhein-Westfalen
ESSEN

GLORIA: Single-arm, Dose-Escalation, Phase 1/2 Study of Olaptesed Pegol (NOX-A12) in Combination with Irradiation in Inoperable or Partially Resected First-line Glioblastoma Patients with Unmethylated MGMT Promoter
Universitätsklinikum Essen
Klinik für Neurologie

Sachsen
DRESDEN
AVAGLIO: A randomized, double blind, placebo controlled, multicenter Phase III trial of bevacizumab, temozolomide and radiotherapy, followed by bevacizumab and temozolomide versus placebo, temozolomide and radiotherapy followed by placebo and temozolomide in patients with newly diagnosed glioblastoma - DE
Universitätsklinikum Carl Gustav Carus an der TU Dresden
Klinik und Poliklinik für Neurochirurgie

Sachsen
LEIPZIG
Phase 3b Study for Management of Ocular Side Effects in Subjects With EGFR-amplified Glioblastoma Receiving Depatuxizumab Mafodotin (ABT-414) -DE-
Universitätsklinikum Leipzig AöR
UCCL - Universitäres Krebszentrum Leipzig

Schleswig-Holstein
KIEL
REGAL: A Phase III, randomised, parallel group, multicentre study in recurrent Glioblastoma patients to compare the efficacy of Cediranib (RECENTIN, AZD2171) monotherapy and the combination of Cediranib with Lomustine to the efficacy of Lomustine alone - DE
Universitätsklinikum Schleswig-Holstein - Campus Kiel
Klinik für Neurochirurgie

WIEN
ADDRESS: NOT PROVIDED - AT

IPAX-1: A multi-centre, open-label, single-arm, dose-finding phase I/II study to evaluate safety, tolerability, dosing schedule, and preliminary efficacy of carrier-added 4-L-[131I]iodo-phenylalanine (131I-IPA), administered as single or repetitive injections in patients with recurrent glioblastoma multiforme, concomitantly to 2nd line external radiation therapy - AT
Institution: Information not provided - AT

WIEN
ADDRESS: NOT PROVIDED - AT


MIRAGE: A Phase III Trial of Marizomib in Combination With Standard Temozolomide-based Radiochemotherapy Versus Standard Temozolomide-based Radiochemotherapy Alone in Patients With Newly Diagnosed Glioblastoma - AT
Institution: Information not provided - AT

WIEN
ADDRESS: NOT PROVIDED - AT

IDH mutated 1p/19q intact lower grade glioma following resection: Wait Or Treat? IWOT - A phase III study - AT
Institution: Information not provided - AT

WIEN
WIEN

CheckMate 548: A Randomized Phase 3 Single Blind Study of Temozolomide Plus Radiation Therapy Combined With Nivolumab or Placebo in Newly Diagnosed Adult Subjects With MGMT-Methylated (Tumor O6-methylguanine DNA Methyltransferase) Glioblastoma - AT
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Onkologie

WIEN
WIEN
CheckMate 498: A Randomized Phase 3 Open Label Study of Nivolumab vs Temozolomide Each in Combination With Radiation Therapy in Newly Diagnosed Adult Subjects With Unmethylated MGMT (Tumor O-6-methylguanine DNA Methyltransferase) Glioblastoma - AT
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Onkologie

WIEN
WIEN
Intellance 1: A Randomized, Placebo Controlled Phase 2b/3 Study of ABT-414 With Concurrent Chemoradiation and Adjuvant Temozolomide in Subjects With Newly Diagnosed Glioblastoma (GBM) With Epidermal Growth Factor Receptor (EGFR) Amplification - AT
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Onkologie

WIEN
WIEN

Phase III Intergroup Study of Radiotherapy With Concomitant and Adjuvant Temozolomide Versus Radiotherapy With Adjuvant PCV Chemotherapy in Patients With 1p/19q Co-deleted Anaplastic Glioma or Low Grade Glioma - AT
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Onkologie

WIEN
WIEN


STEAM: Study of TG02 in Elderly Newly Diagnosed or Adult Relapsed Patients With Anaplastic Astrocytoma or Glioblastoma: A Phase Ib Study - AT
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Onkologie

WIEN
WIEN

HERBY: A Phase II Open-Label, Randomized, Multi-Centre Comparative Study Of Bevacizumab-Based Therapy In Paediatric Patients With Newly Diagnosed Supratentorial, Infratentorial Cerebellar, or Peduncular High-Grade Glioma - AT
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Neonatologie, Pädiatrische Intensivmedizin und Neuropädiatrie

WIEN
WIEN
Pharmacokinetics of temozolomide in cerebrospinal fluid in children with malignant brain tumors (phase 1)
Allgemeines Krankenhaus der Stadt Wien
Klinische Abteilung für Neonatologie, Pädiatrische Intensivmedizin und Neuropädiatrie

ANTWERPEN
ANTWERPEN

EORTC 26081-22086/CODEL: Phase III intergroup Study of Radiotherapy versus Temozolomide Alone versus Radiotherapy with concomitant and adjuvant Temozolomide for Patients with 1p/19q Codeleted Anaplastic Glioma - BE
Ziekenhuis Netwerk Antwerpen (ZNA) - Campus Middelheim
Oncologie

ANTWERPEN
ANTWERPEN-EDEGEM
ADDIT-GLIO: Adjuvant Dendritic-Cell Immunotherapy Plus Temozolomide Following Surgery and Chemoradiation in Patients With Newly Diagnosed Glioblastoma
University Hospital of Antwerp - UZA
Antwerp University Hospital

ARRONDISSEMENT BRUSSELS-CAPITAL
ADDRESS: NOT PROVIDED - BE


TAVAREC: Randomized trial assessing the significance of Bevacizumab in recurrent grade II and Grade III gliomas. The TAVAREC trial (Phase II) - BE
Institution: Information not provided - BE

ARRONDISSEMENT BRUSSELS-CAPITAL
BRUSSELS
Phase IIb Trial Evaluations Of The Effectiveness Of Treatment Glioblastoma / Gliosarcoma Through The Suppression Of The PI3K/Akt Pathway In Compared With MK-3475 (Pembrolizumab) - BE
Cliniques universitaires Saint-Luc - UCLouvain
Cliniques Universitaires Saint-Luc

ARRONDISSEMENT BRUSSELS-CAPITAL
BRUSSELS
A Randomized Phase II Clinical Trial on the Efficacy of Axitinib as a Monotherapy or in Combination With Lomustine for the Treatment of Patients With Recurrent Glioblastoma
Universitair Ziekenhuis Brussel
NMRC Site UZBrussel

ARRONDISSEMENT BRUSSELS-CAPITAL
BRUSSELS
The CATNON Intergroup trial: Phase III trial on Concurrent and Adjuvant Temozolomide chemotherapy in non-1p/19q deleted anaplastic glioma - BE
Universitair Ziekenhuis Brussel
Neurology

ARRONDISSEMENT BRUSSELS-CAPITAL
BRUSSELS

Phase II Clinical Trial on the Combination of Avelumab and Axitinib for the Treatment of Patients With Recurrent Glioblastoma
Universitair Ziekenhuis Brussel
Universitair Ziekenhuis Brussel (UZ Brussel)

Andalucía
MÁLAGA
GEINOCANN: Ensayo clínico de fase Ib, abierto, multicéntrico, de intensificación de la dosis intrapaciente para evaluar el perfil de seguridad de la combinación TN-TC11G (THC + CBD) con temozolomida y radioterapia en pacientes con glioblastoma recién diagnosticado
Hospital Regional Universitario de Málaga - Hospital General
Unidad de Gestión Clínica Intercentros de Oncología Integral de Málaga

Cataluña
BADALONA
CheckMate 548: Estudio fase 3, aleatorizado, simple ciego, de temozolomida más radioterapia combinados con nivolumab o placebo en sujetos adultos recién diagnosticados de glioblastoma con MGMT (06-metilguanina ADN metiltransferasa tumoral) metilado
Hospital Germans Trias I Pujol

Cataluña
BARCELONA
CheckMate 548: Estudio fase 3, aleatorizado, simple ciego, de temozolomida más radioterapia combinados con nivolumab o placebo en sujetos adultos recién diagnosticados de glioblastoma con MGMT (06-metilguanina ADN metiltransferasa tumoral) metilado
Hospital Clínic de Barcelona

Cataluña
BARCELONA
Estudio clínico de fase 2 de pomalidomida (CC-4047) en monoterapia para niños y adultos jóvenes con tumores cerebrales primarios recurrentes o progresivos
Hospital Universitari Vall d'Hebron

Cataluña
BARCELONA
CheckMate 548: Estudio fase 3, aleatorizado, simple ciego, de temozolomida más radioterapia combinados con nivolumab o placebo en sujetos adultos recién diagnosticados de glioblastoma con MGMT (06-metilguanina ADN metiltransferasa tumoral) metilado
Hospital Universitari Vall d'Hebron

Comunidad Valenciana
VALENCIA
CheckMate 548: Estudio fase 3, aleatorizado, simple ciego, de temozolomida más radioterapia combinados con nivolumab o placebo en sujetos adultos recién diagnosticados de glioblastoma con MGMT (06-metilguanina ADN metiltransferasa tumoral) metilado
Hospital General Universitario de Valencia

Comunidad Valenciana
VALENCIA
Estudio clínico de fase 2 de pomalidomida (CC-4047) en monoterapia para niños y adultos jóvenes con tumores cerebrales primarios recurrentes o progresivos
Hospital Universitario y Politécnico La Fe

Galicia
SANTIAGO DE COMPOSTELA
CheckMate 548: Estudio fase 3, aleatorizado, simple ciego, de temozolomida más radioterapia combinados con nivolumab o placebo en sujetos adultos recién diagnosticados de glioblastoma con MGMT (06-metilguanina ADN metiltransferasa tumoral) metilado
Hospital Clínico Universitario de Santiago
Servicio de Oncología Médica

Madrid
ADDRESS: NOT PROVIDED - ES
Ensayo de fase IIb de evaluación de la eficacia del tratamiento del glioblastoma / gliosarcoma mediante la supresión de la vía PI3K/Akt en comparación con MK-3475 (pembrolizumab)
Institution: Information not provided - ES

Madrid
ADDRESS: NOT PROVIDED - ES
Intellance 1: Estudio aleatorizado, controlado con placebo fase 2b/3 de ABT-414 con quimiorradiación concurrente y temozolomida adyuvante en pacientes recién diagnosticados de glioblastoma (GBM) con amplificación del receptor de factor de crecimiento epidermoide (EGFR)
Institution: Information not provided - ES

Madrid
MADRID
CheckMate 548: Estudio fase 3, aleatorizado, simple ciego, de temozolomida más radioterapia combinados con nivolumab o placebo en sujetos adultos recién diagnosticados de glioblastoma con MGMT (06-metilguanina ADN metiltransferasa tumoral) metilado
Hospital General Universitario Gregorio Marañón

Madrid
MADRID
Estudio clínico de fase 2 de pomalidomida (CC-4047) en monoterapia para niños y adultos jóvenes con tumores cerebrales primarios recurrentes o progresivos
Hospital Infantil Universitario Niño Jesús

Madrid
MADRID
CheckMate 548: Estudio fase 3, aleatorizado, simple ciego, de temozolomida más radioterapia combinados con nivolumab o placebo en sujetos adultos recién diagnosticados de glioblastoma con MGMT (06-metilguanina ADN metiltransferasa tumoral) metilado
Hospital Universitario 12 de Octubre

Madrid
MADRID

GEINOGLAS: Ensayo clínico fase Ib/II sobre la combinación de glasdegib (inhibidor de la vía SHH) y temozolamida en pacientes con diagnóstico de novo de glioblastoma
Hospital Universitario Ramón y Cajal
Servicio de Oncología Médica

California
DUARTE


Phase I Study of Cellular Immunotherapy Using Central Memory Enriched T Cells Lentivirally Transduced to Express an IL13R alpha 2-Specific, Hinge-Optimized, 41BB-Costimulatory Chimeric Receptor and a Truncated CD19 for Patients With Recurrent/Refractory Malignant Glioma - US
City of Hope
City of Hope National Medical Center

California
DUARTE

A Phase I Study of Cytosine Deaminase-Expressing Neural Stem Cells in Combination With Oral 5-Fluorocytosine and Leucovorin for the Treatment of Recurrent High-Grade Gliomas - US
City of Hope
City of Hope National Medical Center

Texas
SAN ANTONIO

A Phase 2, Investigator Initiated Study to Determine the Safety and Efficacy of TH-302 in Combination With Bevacizumab for Glioblastoma Following Bevacizumab Failure - US
University of Texas Health Science Center

AUVERGNE-RHONE-ALPES
BRON

Randomized, Prospective, Multicenter Blinding Singles With Arm A and Arm B Innovative Strategy Strategy Conventional (Phase III) - FR
CHU de Lyon HCL - GH Est-Hôpital Neurologique P. Wertheimer
Service de neurochirurgie tumorale - chirurgie des malformations vasculaires du systéme nerveux

AUVERGNE-RHONE-ALPES
CLERMONT-FERRAND
GLYRad : Phase I/II Study of LY2228820 With Radiotherapy Plus Concomitant TMZ in the Treatment of Newly Diagnosed Glioblastoma
CLCC Jean Perrin

BOURGOGNE-FRANCHE-COMTE
DIJON

Glio-SIB-Up : Multicenter Phase II Study Evaluating the Efficacy of Radiotherapy With Modulation Intensity and Integrated Boost (SIB-IMRT) at the Dose of 80Gy, Associated With Chemotherapy by Temozolomide in the Treatment of Adult Glioblastomas
CLCC Georges François Leclerc
Service de Radiothérapie

ILE-DE-FRANCE
BOBIGNY
REGAL: A Phase III, Randomised, Parallel Group, Multi-Centre Study in Recurrent Glioblastoma Patients to Compare the Efficacy of Cediranib [RECENTIN, AZD2171] Monotherapy and the Combination of Cediranib With Lomustine to the Efficacy of Lomustine Alone - FR
CHU Paris Seine-Saint-Denis - Hôpital Avicenne
Service de Neurologie

ILE-DE-FRANCE
BOBIGNY

Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma- A Randomized Multicenter Trial (Phase III) - FR
CHU Paris Seine-Saint-Denis - Hôpital Avicenne
Service de Neurologie

ILE-DE-FRANCE
PARIS

A Prospective, Multi-center Phase III Trial of NovoTTF-100A Together With Temozolomide Compared to Temozolomide Alone in Patients With Newly Diagnosed Glioblastoma Multiforme
APHP.Sorbonne Université, Hôpital de la Pitié-Salpêtrière
Service de Neurologie 2 : Unité d'Onco-Neurologie

ILE-DE-FRANCE
PARIS

ONCOVIRAC : Safety and Efficacy of the ONCOlytic VIRus Armed for Local Chemotherapy, TG6002/5-FC, in Recurrent Glioblastoma Patients (Phase I-II)
APHP.Sorbonne Université, Hôpital de la Pitié-Salpêtrière
Service de Neurologie 2 : Unité d'Onco-Neurologie

ILE-DE-FRANCE
VILLEJUIF

Phase III intergroup study of radiotherapy versus temozolomide alone versus radiotherapy with concomitant and adjuvant temozolomide for patients with 1p/19q codeleted anaplastic glioma - FR
CLCC Institut Gustave Roussy
Département d'Oncologie Radiothérapie

NORMANDIE
CAEN

OLA-TMZ-RTE-01 : Phase I/IIa Study of Concomitant Radiotherapy With Olaparib and Temozolomide in Unresectable High Grade Gliomas Patients
Centre François Baclesse
Neuro-oncologie

OCCITANIE
TOULOUSE

Study of the Capacity of the MRI Spectroscopy to Define the Tumor Area Enriched in Glioblastoma Stem Cells. Proof of Concept Study - FR
IUCT Oncopole - CLCC Institut Claudius Regaud
Département de radiothérapie

OCCITANIE
TOULOUSE

STERIMGLI : A Phase I/II Multicenter Trial Evaluating the Association of Hypofractionated Stereotactic Radiation Therapy and the Anti-Programmed Death-ligand 1 (PD-L1) Durvalumab (Medi4736) for Patients With Recurrent Glioblastoma
IUCT Oncopole - CLCC Institut Claudius Regaud
Département de radiothérapie

PAYS DE LA LOIRE
SAINT-HERBLAIN


A Phase III Trial of Marizomib in Combination With Standard Temozolomide-based Radiochemotherapy Versus Standard Temozolomide-based Radiochemotherapy Alone in Patients With Newly Diagnosed Glioblastoma-FR
Institut de Cancérologie de l'Ouest (ICO) - site René Gauducheau

PROVENCE-ALPES-COTE D'AZUR
NICE

PAZOGLIO : A Phase I/II Study of Pazopanib in Combination With Temozolomide in Patients With Newly Diagnosed Glioblastoma Multiforme After Surgery and RT-CT
CLCC Antoine Lacassagne
Département d'Hématologie - Oncologie médicale

Limburg
MAASTRICHT

Randomized Assessment of Conventional Neuronavigation Versus Intraoperative MRI for the Neurosurgical Treatment of Glioblastomas
AZM - Academisch Ziekenhuis Maastricht
Afdeling Neurochirurgie

Noord-Holland
AMSTERDAM
The STELLAR Study: A Phase II/III Study of High-dose, Intermittent Sunitinib in Patients With Recurrent Glioblastoma Multiforme
Amsterdam UMC, locatie VUmc
Afdeling Medische Oncologie

Zuid-Holland
LEIDEN

STING: Comparing a Treatment Strategy With Levetiracetam Versus Treatment With Valproic Acid in Glioma Patients With a First Seizure (phase IV)
LUMC - Leids Universitair Medisch Centrum
Afdeling Neurologie

Zuid-Holland
ROTTERDAM
Temozolomide and Radiation Therapy With or Without Vatalanib in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
Erasmus MC, Locatie Daniel den Hoed
Afdeling Neuro-Oncologie

Greater London
LONDON

A Phase III clinical trial evaluating DCVax®-L, autologous dendritic cells (DC) pulsed with tumor lysate antigen for the treatment of glioblastoma multiforme (GBM) - UK
King's College Hospital
Department of Medical Oncology

Greater London
LONDON
Phase 3b Study for Management of Ocular Side Effects in Subjects With EGFR-amplified Glioblastoma Receiving Depatuxizumab Mafodotin (ABT-414)-GB
Kings College School of Medicine
Guy's and St Thomas NHS Foundation Trust

Greater London
LONDON

Greater Manchester
ADDRESS: NOT PROVIDED - UK

Phase III intergroup Study of Radiotherapy versus Temozolomide Alone versus Radiotherapy with concomitant and adjuvant Temozolomide for Patients with 1p/19q Codeleted Anaplastic Glioma - UK
Institution: Information not provided - UK

Greater Manchester
ADDRESS: NOT PROVIDED - UK
EORTC 26082 - 22081: Radiation therapy and concurrent plus adjuvant Temsirolimus (CCI-779) versus chemo-irradiation with Temozolomide in newly diagnosed glioblastoma without methylation of the MGMT gene promoter - a randomized multicenter, open-label, Phase II study - UK
Institution: Information not provided - UK

Greater Manchester
ADDRESS: NOT PROVIDED - UK

PARADIGM-2:OlaPArib and RADIotherapy or olaparib and radiotherapy plus temozolomide in newly-diagnosed Glioblastoma stratified by MGMT status: 2 parallel phase I studies
Institution: Information not provided - UK

Lothian
EDINBURGH


TAVAREC: Randomized trial assessing the significance of Bevacizumab in recurrent grade II and Grade III gliomas. The TAVAREC trial (Phase II) - UK
Edinburgh Cancer Centre

Lothian
EDINBURGH

The CATNON Intergroup trial: Phase III trial on Concurrent and Adjuvant Temozolomide chemotherapy in non-1p/19q deleted anaplastic glioma - UK
Edinburgh Cancer Centre

Lothian
EDINBURGH
RTOG: Phase III trial comparing conventional adjuvant temozolomide with dose-intensive temozolomide in patients with newly diagnosed glioblastoma - UK
Edinburgh Cancer Centre

Suisse Alémanique
BERN
RESDEX - Restrictive Use of Dexamethasone in Glioblastoma
University Hospital Inselspital
Universitätsklinik für Neurochirurgie

Suisse Alémanique
ZÜRICH

CheckMate 548: A Randomized Phase 3 Single Blind Study of Temozolomide plus Radiation Therapy combined with Nivolumab or Placebo in Newly Diagnosed Adult Subjects with MGMT-Methylated (tumor O6-methylguanine DNA methyltransferase) Glioblastoma - CH
Universitätsspital Zürich
Klinik für Neurologie und Labor für Molekulare Neuro-Onkologie

Suisse Romande
ADDRESS: NOT PROVIDED - CH
A Phase 2 clinical study of pomalidomide (CC-4047) monotherapy for children and young adults with recurrent or progressive primary brain tumors. -GB
Institution: Information not provided - CH

ARRONDISSEMENT BRUSSELS-CAPITAL
BRUSSELS
STEP: Sorafenib Long Term Extension Program - BE
Cliniques universitaires Saint-Luc - UCLouvain
Pneumologie_Oncologie thoracique
Ensayo(s) clínico(s) multinacional(es)

AUVERGNE-RHONE-ALPES
ADDRESS: NOT PROVIDED - FR
VINILO: Phase I-II Study of Vinblastine in Combination With Nilotinib in Children, Adolescents, and Young Adults With Refractory or Recurrent Low-Grade Glioma
Institution: Information not provided - FR

Leicestershire
LEICESTER
CNS 2004 03: Cooperative Multicentre Study For Children And Adolescents With Low Grade Glioma (Phase III) (coordination)
Leicester Univ. Hosp. NHS - Leicester Royal Infirmary
University Hospitals of Leicester NHS Trust Headquarters

Baden-Württemberg
HEIDELBERG
An open-label, Phase I/II multicenter clinical trial of VXM01 in combination with avelumab in patients with progressive glioblastoma following standard treatment with or without second surgery
Neurologische Universitätsklinik Heidelberg
Abteilung für Neuroonkologie

Baden-Württemberg
TÜBINGEN
GAPVAC: Glioma actively personalized vaccine consortium
Immatics Biotechnologies GmbH

Bayern
MUNICH

ARRONDISSEMENT BRUSSELS-CAPITAL
ADDRESS: NOT PROVIDED - BE
TAVAREC: Randomized trial assessing the significance of Bevacizumab in recurrent grade II and Grade III gliomas (Phase II)
Institution: Information not provided - BE

ARRONDISSEMENT BRUSSELS-CAPITAL
ADDRESS: NOT PROVIDED - BE
CODEL: Phase III intergroup study of Radiotherapy versus Temozolomide alone versus Radiotherapy with concomitant and adjuvant Temozolomide for patients with 1p/19q codeleted Anaplastic Glioma
Institution: Information not provided - BE

ARRONDISSEMENT BRUSSELS-CAPITAL
ADDRESS: NOT PROVIDED - BE
Phase III trial exploring the combination of bevacizumab and lomustine in patients with first recurrence of a glioblastoma.
Institution: Information not provided - BE

ARRONDISSEMENT BRUSSELS-CAPITAL
BRUSSELS
CheckMate 548: A Randomized Phase 2 Single Blind Study of Temozolomide plus Radiation Therapy combined with Nivolumab or Placebo in Newly Diagnosed Adult Subjects with MGMT-Methylated (tumor O6-methylguanine DNA methyltransferase) Glioblastoma
Bristol Myers Squibb International Corporation

ARRONDISSEMENT BRUSSELS-CAPITAL
BRUSSELS
IWOT: IDH mutated 1p/19q intact lower grade glioma following resection: Wait Or Treat? - A phase III study
EORTC
European Organisation for the Research and Treatment of Cancer

New Jersey
HAMPTON

Pennsylvania
PHILADELPHIA
Phase I/II Trial of Concurrent RAD001 (Everolimus) With Temozolomide/Radiation Followed by Adjuvant RAD001/Temozolomide in Newly Diagnosed Glioblastoma
RADIATION THERAPY ONCOLOGY GROUP

Washington
ADDRESS: NOT PROVIDED - US
A Phase 2 clinical study of pomalidomide (CC-4047) monotherapy for children and young adults with recurrent or progressive primary brain tumors.
Institution: Information not provided - US

HAUTS-DE-FRANCE
LILLE

ILE-DE-FRANCE
PARIS

GREECE
ADDRESS: NOT PROVIDED - GR
Exploratory Phase II Study in Patients After Treatment of High Grade Brain Tumors to Assess the Technical Performance of Tc-99m Tetrofosmin for Differentiation of Recurrence Versus Radiation Necrosis
Institution: Information not provided - GR

ISRAEL
TIRAT CARMEL
A prospective, multicenter phase III trial of NovoTTF-100A together with Temozolomide compared to Temozolomide alone in patients with newly diagnosed Glioblastoma Multiforme (GBM) (coordination)
NOVOCURE
Novocure Ltd.

Greater Manchester
ADDRESS: NOT PROVIDED - UK
Phase IIb Trial Evaluations Of The Effectiveness Of Treatment Glioblastoma / Gliosarcoma Through The Suppression Of The PI3K/Akt Pathway In Compared With MK-3475 (Pembrolizumab)
Institution: Information not provided - UK

Surrey
WINDLESHAM
Randomized phase III open label study - Enzastaurin vs. Lomustine in glioblastoma (coordination)
Eli Lilly Holdings Limited

Suisse Alémanique
BASEL
A Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy of Bevacizumab, Radiotherapy and Temozolomide (TMZ) Followed by Bevacizumab and TMZ, Versus Placebo Radiotherapy and TMZ Followed by Placebo and TMZ on Survival in Patients With Newly Diagnosed Glioblastoma (Phase III) (coordination)
Hoffmann-La Roche
Hoffmann - La Roche Ltd.

Suisse Alémanique
BASEL
EXIST-1: A randomized, double-blind, placebo-controlled Phase III Study of Everolimus (RAD001) in the treatment of patients with Subependymal Giant Cell Astrocytomas (SEGA) associated with Tuberous Sclerosis Complex- coordination
Novartis International AG

Suisse Alémanique
ZÜRICH
A Phase III Trial of Marizomib in Combination With Standard Temozolomide-based Radiochemotherapy Versus Standard Temozolomide-based Radiochemotherapy Alone in Patients With Newly Diagnosed Glioblastoma
Universitätsspital Zürich
Klinik für Neurologie und Labor für Molekulare Neuro-Onkologie

Suisse Romande
ADDRESS: NOT PROVIDED - CH