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Financé par un membre IRDiRC =

Projets de recherche

IRLANDE

County Dublin
DUBLIN

PORTUGAL

NORTE
PORTO

SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias
Instituto de Biologia Molecular e Celular
Centro de Genética Preditiva e Preventiva

PORTUGAL

NORTE
PORTO

Clinical implications of genetic factors causing neurodegenerative diseases characterized by movement or cognitive dysfunction.
Instituto de Biologia Molecular e Celular
Unidade de Investigação Genética e Epidemiológica em Doenças Neurológicas

PORTUGAL

NORTE
PORTO

Mapping and identification of new disease genes in autosomal dominant spinocerebellar ataxias
Instituto de Biologia Molecular e Celular
Unidade de Investigação Genética e Epidemiológica em Doenças Neurológicas

PORTUGAL

NORTE
PORTO

SPATAX: Clinical and Genetic Analysis of Cerebellar Ataxias and Spastic Paraplegias
Instituto de Biologia Molecular e Celular
Unidade de Investigação Genética e Epidemiológica em Doenças Neurológicas

PORTUGAL

NORTE
SANTA MARIA DA FEIRA

ROYAUME-UNI

Greater London
LONDON

Endogenous Cerebellar Human Stem Cells and their Potential Neuroregenerative Role in Inherited Ataxias
Barts and The London School of Medicine and Dentistry
Centre for Neuroscience and Trauma

ROYAUME-UNI

Lothian
EDINBURGH

Developing non-invasive therapeutic technology to improve motor coordination in cerebellar ataxias
PMARC - The University of Edinburgh
Perception-Movement-Action Research Consortium

ROYAUME-UNI

Lothian
EDINBURGH

Developing non-invasive therapeutic technology to improve motor coordination in cerebellar ataxias
School of Informatics, The University of Edinburgh
Human Communication Research Centre

ETATS-UNIS

Arizona
PHOENIX

Financé par un membre IRDiRCThe etiology of inherited neurological diseases
Phoenix Children's Hospital
Barrow Neurological Institute

ALLEMAGNE

Baden-Württemberg
TÜBINGEN

Financé par un membre IRDiRCSCA-CYP: Gene Therapy for Cerebellar Ataxias: restoring cholesterol metabolism by targeting brain cholesterol 24 hydroxylase (CYP46A1) (partner No 3)
Institut für Medizinische Genetik und angewandte Genomik Tübingen
Institut für Medizinische Genetik und angewandte Genomik

ALLEMAGNE

Hessen
FRANKFURT AM MAIN

CAG102-knock-in model for spinocerebellar ataxia type 2
Klinikum der Johann Wolfgang Goethe-Universität Frankfurt
Klinik für Neurologie

ALLEMAGNE

Nordrhein-Westfalen
BONN

ESPAGNE

Cataluña
BADALONA

Financé par un membre IRDiRCGenetic-molecular basis of hereditary ataxias: characterization of the underlying pathophysiological mechanisms in spinocerebellar ataxias types 37 (SCA37) and 44 (SCA44)
Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol
Unidad de investigación en neurogenética

ESPAGNE

Madrid
MADRID

ETATS-UNIS

Washington
ADDRESS: NOT PROVIDED - US

Financé par un membre IRDiRCNatural history of spinocerebellar ataxia type 7 (sca7)
Institution: Information not provided - US

ETATS-UNIS

Washington
ADDRESS: NOT PROVIDED - US

FRANCE

GRAND-EST
ILLKIRCH-GRAFFENSTADEN

Etude du potentiel prolifératif et régénératif des photorécepteurs dans le modèle murin SCA7, une maladie par expansion de polyglutamine
Institut de génétique et de biologie moléculaire et cellulaire - IGBMC
Département Médecine translationnelle et neurogénétique

FRANCE

ILE-DE-FRANCE
PARIS

BIOSCA: Identification de biomarqueurs de l' évolution de la maladie dans les ataxies cérébelleuses autosomiques dominantes
APHP.Sorbonne Université, Hôpital de la Pitié-Salpêtrière
UF de Neurogénétique Moléculaire et Cellulaire

ITALIE

LOMBARDIA
MILANO

Financé par un membre IRDiRCA drosophila model to study the neurodegenerative disease Dentatorubral-pallidoluysian atrophy
IRCCS Ospedale San Raffaele
Divisione di Genetica e Biologia Cellulare - Dipartimento di Genomica Funzionale

JAPON

JAPAN
NIIGATA

Financé par un membre IRDiRCDevelopment of therapeutic strategy for DRPLA based on gene silencing and genome editing.
Brain Research Institute, Niigata University
Department of Neurology

JAPON

JAPAN
TOKYO

Financé par un membre IRDiRCDeveloping antisense ol igonucleotide therapy targeting bidirectional transcription underlying an inherited neurodegenerative disease.
Tokyo Medical and Dental University Medical Hospital
Center for Personalized Medicine for Healthy Aging

JAPON

JAPAN
TOKYO

Financé par un membre IRDiRCGene therapy against SCA1 based on the molecular pathomechanism
Tokyo Medical and Dental University Medical Research Institute
Department of Neuropathology

PORTUGAL

CENTRO
ADDRESS: NOT PROVIDED - PT

PORTUGAL

CENTRO
ADDRESS: NOT PROVIDED - PT

PORTUGAL

CENTRO
BRAGA

PORTUGAL

CENTRO
COIMBRA

The role of calpain-mediated proteolysis of ataxin-3 in Machado-Joseph disease: a molecular therapy approach with viral vectors.
Centro de Neurociências da Universidade de Coimbra
Departmento de vectores e terapia génica

PORTUGAL

CENTRO
COIMBRA

Regulation by phosphorylation of ataxin-3, the mutated protein in Machado Joseph Disease
Centro de Neurociências da Universidade de Coimbra
Glutamatergic Synapses: Formation and regulation of synapses

PORTUGAL

NORTE
PORTO

A peptide aptamer-based approach to neurodegenerative disorders.
Instituto de Biologia Molecular e Celular
Protein Crystallography Group

PORTUGAL

NORTE
PORTO

CACNA1A gene involvement in cognition and synaptic function in calcium channel disease.
Instituto de Biologia Molecular e Celular
Unidade de Investigação Genética e Epidemiológica em Doenças Neurológicas

PORTUGAL

NORTE
PORTO

Search for disease modifiers in spinocerebellar ataxias: human and animal-based approaches.
Instituto de Biologia Molecular e Celular
Unidade de Investigação Genética e Epidemiológica em Doenças Neurológicas

SUEDE

Stockholms läns landsting
STOCKHOLM

The role of an atrophin-brakeless protein complex in gene regulation and neurodegeneration in particularly
Stockholm University
Department of Molecular Biosciences, The Wenner-Gren Institute (MBW)

SUISSE

Suisse Romande
LAUSANNE

FRANCE

ILE-DE-FRANCE
PARIS

Financé par un membre IRDiRCSTaHR : Stimulation de la Recombinaison Homologue pour la Thérapie Génique - FR
Muséum National d'Histoire Naturelle
Laboratoire Structure et Instabilité des Génomes - INSERM U1154 - CNRS 7196

FRANCE

PAYS DE LA LOIRE
NANTES

Financé par un membre IRDiRCFROGH : Etude Génétique de la Population Française - FR
Institut de Recherche en Santé - Université de Nantes
L'Institut du thorax - Inserm UMR 1087 / CNRS UMR 6291

JAPON

JAPAN
TOKYO

Financé par un membre IRDiRCFormation of integrated omics analysis base of refractory diseases in children and perinatal period
National Center for Child Health and Development
Research Institute

Projets de recherche multicentriques