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Onderzoeksprojecten

BELGIË

ARRONDISSEMENT BRUSSELS-CAPITAL
BRUSSELS

BELGIË

ARRONDISSEMENT BRUSSELS-CAPITAL
BRUSSELS

FLONAMUC: Epidemiology of the Nasal Flora at the Reference Center for Cystic Fibrosis of Queen Fabiola Children's University Hospital
Hôpital Universitaire des Enfants Reine Fabiola - HUDERF
Service de Pneumologie-Allergologie

BELGIË

ARRONDISSEMENT BRUSSELS-CAPITAL
BRUSSELS

MucoSWEATomics New Markers of CFTR Function in Sweat: Value for Diagnosis and Efficacy of Target Therapies
Université Catholique de Louvain (UCL)
Louvain centre for Toxicology and Applied Pharmacology

BELGIË

ARRONDISSEMENT BRUSSELS-CAPITAL
BRUXELLES

Efflux as a mechanism of intrinsic and acquired resistance to antibiotics in Achromobacter xylosoxidans
Cellular and Molecular Pharmacology Unit, Louvain Drug Research Institute, UCL
Cellular and Molecular Pharmacology Unit

BELGIË

ARRONDISSEMENT BRUSSELS-CAPITAL
BRUXELLES

Development of CFTR-stabilizers as therapeutic for cystic fibrosis
Structure et Fonction des Membranes Biologiques
Laboratoire Structure et Fonction des Membranes Biologiques

BELGIË

OOST-VLAANDEREN
GENT

Ontwikkeling van een gepersonaliseerde aanpak voor het testen van gevoeligheid aan antibiotica
LPM Pharmaceutical Microbiology, Universiteit Gent
LPM Laboratory of Pharmaceutical Microbiology

BELGIË

VLAAMS BRABANT
LEUVEN

Ontwikkeling van therapieën voor zeldzame mutaties die ernstige mucoviscidose veroorzaken
Center for molecular medicine, Division of Molecular Virology and Gene Therapy
Molecular Virology and Gene Therapy

BELGIË

VLAAMS BRABANT
LEUVEN

Evaluatie van de CFTR functie in organoïden ('minidarmpjes') verkregen uit rectale biopsieën van mucoviscidosepatiënten
University Hospitals Leuven - Gasthuisberg
Dienst Kindergeneeskunde/Department of Pediatrics

BELGIË

VLAAMS BRABANT
LEUVEN

Het endotheel als centrale speler in leveraantasting door mucoviscidose
University Hospitals Leuven - Gasthuisberg
UZ Leuven

CANADA

Colombie-Britannique
VANCOUVER

Mechanisms of Hyperinfammation in Cystic Fibrosis
Centre for Microbial Diseases and Immunity Research

CANADA

Nouvelle-Écosse
HALIFAX

Gefinancierd door een IRDiRC-lidFunctional Architecture of the CFTR Chloride Channel
Dalhousie University
Department of Physiology & Biophysics

CANADA

Nouvelle-Écosse
HALIFAX

Regulation of CFTR membrane stability and function by VIP
Dalhousie University
Department of Physiology & Biophysics

CANADA

Ontario
TORONTO

Gefinancierd door een IRDiRC-lidEvaluating the Mechanism of Action of Small Molecule Modulators of CFTR
Hospital for Sick Children, Research Institute

CANADA

Ontario
TORONTO

Pathophysiology of Cystic Fibrosis Lung Disease
Hospital for Sick Children, Research Institute
Paediatric Laboratory Medicine

CANADA

Ontario
TORONTO

Gefinancierd door een IRDiRC-lidEnsuring effective newborn screening: The case of cystic fibrosis
University of Toronto
Institute of Health Policy, Management and Evaluation

CANADA

Québec
MONTRÉAL

Screening for abnormalities related to glucose tolerance secondary to cystic fibrosis
Institut de recherches cliniques de Montréal
Plateforme de recherche en obésité, métabolisme et diabète

CANADA

Québec
MONTRÉAL

Gefinancierd door een IRDiRC-lidNeutrophilic inflammation in Cystic Fibrosis
Meakins-Christie Laboratories

DUITSLAND

Berlin
BERLIN

Gefinancierd door een IRDiRC-lidCORD : Collaboration On Rare Diseases
Geschäftsstelle BIH
Berliner Institut für Gesundheitsforschung

FRANKRIJK

AUVERGNE-RHONE-ALPES
GRENOBLE

FRANKRIJK

AUVERGNE-RHONE-ALPES
GRENOBLE

Muscular function & cystic fibrosis
Université Joseph Fournier
Laboratoire de Recherche Exercice-Santé

FRANKRIJK

BOURGOGNE-FRANCHE-COMTE
BESANÇON

FRANKRIJK

BRETAGNE
BREST

Study of the involvement of pulmonary neuroendocrine cells in cystic fibrosis
CHU de Brest - Hôpital de la Cavale Blanche
Laboratoire de génétique moléculaire et d'histocompatibilité

FRANKRIJK

CENTRE-VAL DE LOIRE
ORLEANS

Cellular and molecular interactions between proteins E3-14.7K / FIP-1 and microtubules in cystic fibrosis
Centre de biophysique moléculaire
Glycobiologie vectorologie et trafic intracellulaire

FRANKRIJK

CENTRE-VAL DE LOIRE
TOURS

Induction of neutrophilic traps (NETs) by the inflammation and infectious pulmonary environment of cystic fibrosis
Faculté de pharmacie de Tours
Unité INSERM U618 "Protéases et Vectorisation Pulmonaires"

FRANKRIJK

CENTRE-VAL DE LOIRE
TOURS

Identification of ligands of human lung cells and production of vectors derived from HPV to lung targeting in cystic fibrosis
Faculté de pharmacie de Tours
Unité INSERM U618 "Protéases et Vectorisation Pulmonaires"

FRANKRIJK

GRAND-EST
REIMS

Does the mutation of the CFTR contributes to the bone fragility in cystic fibrosis?
Université de Reims - UFR des sciences exactes et naturelles
INSERM UMR-S 926 "Interfaces Biomatériaux / Tissus Hôtes"

FRANKRIJK

HAUTS-DE-FRANCE
VILLENEUVE D'ASCQ

Regulation and control of the biosynthesis of sialyl Lewisx and 6-sulfo sialyl Lewisx, ligands of Pseudomonas aeruginosa in human bronchial mucosa in cystic fibrosis
Faculté des Sciences et Technologies - Université de Lille
UGSF - Unité de glycobiologie structurale et fonctionnelle

FRANKRIJK

HAUTS-DE-FRANCE
VILLENEUVE D'ASCQ

Study of the expression and the glycosylation of DMBT1 by the parietal glycoconjugates (LPS and alginate) of Pseudomonas aeruginosa from patients with cystic fibrosis
Faculté des Sciences et Technologies - Université de Lille
UGSF - Unité de glycobiologie structurale et fonctionnelle

FRANKRIJK

ILE-DE-FRANCE
CRÉTEIL

Contribution to the study of the CFTR interactome: dynamics and role of a CFTR-containing complex in inflammation in cystic fibrosis
Faculté de Médecine de Créteil
Equipe "Immunopathologie rénale et immunomodulation en transplantation"

FRANKRIJK

ILE-DE-FRANCE
GARCHES

Mycobacterium abscessus - phagocytic cells CFTR-/ - and particular susceptibility of CF patients
CHU Paris IdF Ouest - Hôpital Raymond Poincaré
Service de microbiologie

FRANKRIJK

ILE-DE-FRANCE
PARIS

Implementation of non-invasive prenatal diagnosis of rare and severe monogenic diseases
CHU Paris Centre - Hôpital Cochin, Site Cochin
Service de génétique et biologie moléculaires

FRANKRIJK

ILE-DE-FRANCE
PARIS

Assessment of perfusion pressures on introduced catheter chamber in adult patients with cystic fibrosis
CHU Paris Centre - Hôpital Cochin, Site Cochin
Service de pneumologie - CRCM

FRANKRIJK

ILE-DE-FRANCE
PARIS

Tracheal malformations in cystic fibrosis: fundamental studies and clinical investigation
CHU Paris Est - Hôpital d'Enfants Armand-Trousseau
Service de pneumologie pédiatrique

FRANKRIJK

ILE-DE-FRANCE
PARIS

Indications and benefits of nocturnal oxygen therapy in cystic fibrosis
CHU Paris Est - Hôpital d'Enfants Armand-Trousseau
Service de pneumologie pédiatrique

FRANKRIJK

ILE-DE-FRANCE
PARIS

Modulation of alveolar macrophage and bronchial epithelial cells function by the antimicrobial/antelastase elafin molecule in cystic fibrosis patients
Faculté de Médecine Paris Diderot Paris 7 - site Bichat
Physiopathologie et Epidémiologie des Maladies respiratoire - INSERM UMR 1152

FRANKRIJK

ILE-DE-FRANCE
PARIS

FRANKRIJK

ILE-DE-FRANCE
PARIS

NEUPROCF: new diagnostic and prognostic biomarkers in cystic fibrosis (coordination)
Faculté de médecine Paris-Descartes, Site Necker
Département "Biologie cellulaire" - Equipe "Canalopathies épitheliales: Mucoviscidose et autres maladies"

FRANKRIJK

ILE-DE-FRANCE
PARIS

Genotype-phenotype study of CFTR from a new model of human respiratory epithelium of cystic fibrosis
Faculté de médecine Paris-Descartes, Site Necker
Département "Biologie cellulaire" - Equipe "Canalopathies épitheliales: Mucoviscidose et autres maladies"

FRANKRIJK

ILE-DE-FRANCE
PARIS

Validation of the assessment of bone mineralization by quantitative computed tomography in patients with cystic fibrosis
Faculté de médecine Paris-Descartes, Site Necker
Département "Biologie cellulaire" - Equipe "Canalopathies épitheliales: Mucoviscidose et autres maladies"

FRANKRIJK

ILE-DE-FRANCE
PARIS

Virulence of Mycobacterium abscessus: role of surface glycopeptidolipids in cystic fibrosis
Faculté de médecine Paris-Descartes, Site Necker
Analyse génétique de l'enveloppe mycobactérienne

FRANKRIJK

ILE-DE-FRANCE
PARIS

Prospective study of the psychopathology of adolescents with cystic fibrosis
Hôpital Necker-Enfants Malades
Unité de pneumo-allergologie pédiatrique

FRANKRIJK

ILE-DE-FRANCE
PARIS

Three-dimensional structure modeling of CFTR: predicting the impact of mutations and binding sites of markers / potentiators in cystic fibrosis patients
IMPMC - Institut de Minéralogie et de Physique des Milieux Condensés
Protein Structure Prediction

FRANKRIJK

ILE-DE-FRANCE
VERSAILLES

Highlight CNG cation channels (cyclic nucleotide-gated cation channels) in the bronchial epithelium and bronchiolar airways of human with cystic fibrosis or not
Université de Versailles Saint-Quentin
Laboratoire Mécanismes pharmacologiques et moléculaires de l' obstruction bronchique

FRANKRIJK

ILE-DE-FRANCE
VILLEJUIF

Gefinancierd door een IRDiRC-lidTransition Platforms: Understanding the Expectations of Parents of Young People with Rare Diseases
CLCC Institut Gustave Roussy
Equipe Epidémiologie des radiations, épidémiologie clinique des cancers et survie

FRANKRIJK

NOUVELLE AQUITAINE
POITIERS

FRANKRIJK

OCCITANIE
MONTPELLIER

Measuring the impact of surgery on nasosinusienne ENT symptoms and sleep quality in patients with cystic fibrosis
CHU de Montpellier - Hôpital Arnaud de Villeneuve
Service des maladies respiratoires

FRANKRIJK

OCCITANIE
MONTPELLIER

DNA glycomimetics to prevent the adherence of Pseudomonas aeruginosa - impact in cystic fibrosis
Faculté de Pharmacie
Département oligonucléotides modifiés

FRANKRIJK

OCCITANIE
MONTPELLIER

Study of CFTR gene's transcriptional regulation in cystic fibrosis
IURC - Institut Universitaire de Recherche Clinique
Laboratoire de génétique moléculaire

FRANKRIJK

OCCITANIE
MONTPELLIER

FRANKRIJK

OCCITANIE
MONTPELLIER

Identification of new regulatory actors in the noncoding regions of CFTR gene: the microRNA and cystic fibrosis
IURC - Institut Universitaire de Recherche Clinique
Laboratoire de génétique moléculaire

FRANKRIJK

OCCITANIE
MONTPELLIER

Study of virulence factor MGTC and its inhibition by a natural peptide in Pseudomonas aeruginosa and in non-tuberculous mycobacteria - impact in cystic fibrosis
Université Montpellier II
Laboratoire de dynamique des interactions membranaires normales et pathologiques - Case 107

FRANKRIJK

OCCITANIE
TOULOUSE

Effect of CFTR on the intra-enterocyte cholesterol in patients with cystic fibrosis
CHU de Toulouse - Hôpital Purpan
Département lipoprotéines et médiateurs lipidiques

FRANKRIJK

PAYS DE LA LOIRE
NANTES

CFTR gene expression in the pulmonary epithelium by targeted gene transfer in cystic fibrosis
Faculté de médecine de Nantes
Physiopathologie et pharmacologie cellulaire et moléculaire

FRANKRIJK

PAYS DE LA LOIRE
NANTES

Reduced lung inflammation in cystic fibrosis by inhibiting the expression of key genes by RNA interference
Faculté de médecine de Nantes
Physiopathologie et pharmacologie cellulaire et moléculaire

IERLAND

County Dublin
DUBLIN

The natural history of cystic fibrosis liver disease - refining the phenotype
Our Lady's Children's Hospital
Gastroenterology Department

IERLAND

County Dublin
DUBLIN

SHIELD CF - The Study of Host Immunity and Early Lung Disease in Cystic Fibrosis
Our Lady's Children's Hospital
Respirology Department

IERLAND

County Dublin
DUBLIN

SHIELD CF - The Study of Host Immunity and Early Lung Disease in Cystic Fibrosis
Tallaght University Hospital
Specialist Cystic Fibrosis Centre

IERLAND

County Dublin
DUBLIN

The natural history of cystic fibrosis liver disease - refining the phenotype
The Catherine McAuley Education & Research Centre
UCD School of Medicine

IERLAND

County Limerick
LIMERICK

SHIELD CF - The Study of Host Immunity and Early Lung Disease in Cystic Fibrosis
University Hospital Limerick
Cystic Fibrosis Clinic

ITALIË

LAZIO
ROMA

Anti-inflammatory therapy with dexamethasone slow release in the control of lung inflammation in patients with Cystic Fibrosis
IRCCS Ospedale Pediatrico Bambino Gesù - SEDE GIANICOLO
U.O. di Epatologia, Gastroenterologia e Nutrizione

ITALIË

LOMBARDIA
MILANO

Gefinancierd door een IRDiRC-lidRescueCFTRpreclinic: Cysteamine for the treatment of cystic fibrosis: a translational research project - IT
IRCCS Ospedale San Raffaele
Centro di Genomica, Bioinformatica e Biostatistica - Unità di Genetica Umana e Molecolare

OOSTENRIJK

WIEN
WIEN

Lung microbiome for screening imminent exacerbation in CF (cystic fibrosis)
Medizinische Universität Wien
Forschungslabor Infektionsbiologie

PORTUGAL

SUL
LISBOA

Elucidating the role of novel CFTR interactors - new mechanisms in membrane protein trafficking.
Faculdade de Ciências da Universidade de Lisboa
Membrane Protein Disorders Unit

PORTUGAL

SUL
LISBOA

Diagnosis, Prognosis and Treatment of Cystic Fibrosis
Faculdade de Ciências da Universidade de Lisboa
Membrane Protein Disorders Unit

PORTUGAL

SUL
LISBOA

Characterization of ER-quality control for the F508del-CFTR protein: potential therapeutic targets for cystic fibrosis
Faculdade de Ciências da Universidade de Lisboa
Membrane Protein Disorders Unit

PORTUGAL

SUL
LISBOA

Identification of Novel Targets Rescuing of F508del-CFTR Traffic: Mechanism of Action
Faculdade de Ciências da Universidade de Lisboa
Membrane Protein Disorders Unit

PORTUGAL

SUL
OEIRAS

Biochemical and Structural Studies of UDP-Glucose Dehydrogenases.
Instituto de Tecnologia Química e Biológica
Unidade de Cristalografia Macromolecular

VERENIGD KONINKRIJK

Avon
BRISTOL

EUROCARE CF: European coordination action for research in cystic fibrosis (coordination)
University of Bristol
Department of Physiology and Pharmacology

VERENIGD KONINKRIJK

Greater London
LONDON

Air Pollution and Children With Cystic Fibrosis -GB
Queen Mary University of London Headquarters

VERENIGD KONINKRIJK

Greater Manchester
MANCHESTER

VERENIGD KONINKRIJK

Lothian
EDINBURGH

Gefinancierd door een IRDiRC-lidInflammation in Cystic Fibrosis Lung Disease: Defining the Role of Calprotectin
Western General Hospital
Edinburgh Cancer Research Centre

VERENIGD KONINKRIJK

Warwickshire
COVENTRY

ZWITSERLAND

Suisse Alémanique
BERN

Multiple Breath Washout in Children with Cystic Fibrosis: Transition from a Specialised Tool to Clinical Implementation
Inselspital Universitätsspital
Abteilung für pädiatrische Pneumologie und Allergologie

ZWITSERLAND

Suisse Alémanique
BERN

ZWITSERLAND

Suisse Romande
GENÈVE

Intercellular signaling in cystic Fibrosis airway innate host defense mechanisms
Centre Médical Universitaire - CMU
Département de physiologie cellulaire et métabolisme

FRANKRIJK

ILE-DE-FRANCE
PARIS

Gefinancierd door een IRDiRC-lidSTaHR : Stimulation of Targeted Homologous Recombination for Gene Therapy - FR
Muséum National d'Histoire Naturelle
Laboratoire Structure et Instabilité des Génomes - INSERM U1154 - CNRS 7196

FRANKRIJK

PAYS DE LA LOIRE
NANTES

Gefinancierd door een IRDiRC-lidFROGH : FRench Regional Origins in Genetics for Health - FR
Institut de Recherche en Santé - Université de Nantes
L'Institut du thorax - Inserm UMR 1087 / CNRS UMR 6291

JAPAN

JAPAN
TOKYO

Gefinancierd door een IRDiRC-lidFormation of integrated omics analysis base of refractory diseases in children and perinatal period
National Center for Child Health and Development
Research Institute

Multicentrische onderzoeksprojecten