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Disease definition

A rare dermatosis, which can be either localized or generalized, that occurs after prolonged contact and absorption of silver containing compounds over a period of years and that is characterized by irreversible blue-gray to gray-black staining of skin, fingernails and/or mucous membranes, most evident on sun exposed areas of the skin. Silver exposure is usually occupational but may also occur through dental amalgams, the ingestion of colloidal silver, acupuncture needles, orthopedic implants and topical medications (such as silver sulfadiazine).


Classification level: Disorder

  • Silver staining

Prevalence: Unknown

Inheritance: Not applicable

Age of onset: All ages

ICD-10: T56.8

ICD-11: ED6Y

UMLS: C0003782

MeSH: D001129

MedDRA: 10003094

A summary on this disease is available in Français (2005) Español (2014) Deutsch (2005) Nederlands (2014)
Additional information

Further information on this disease

Research activities on this disease

Specialised Social Services

Newborn screening

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