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Antiphospholipid syndrome

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Disease definition

A rare systemic autoimmune disease characterized by hypercoagulability with vascular thrombosis and, in women, pregnancy morbidity (miscarriages, severe pre-eclampsia, placental insufficiency) in the presence of serum antiphospholipid antibodies, such as lupus anticoagulant, anticardiolipin antibodies, and anti-beta2-glycoprotein 1 antibodies.


Classification level: Disorder

  • APLS
  • Antiphospholipid antibody syndrome
  • Classic APLS
  • Classic antiphospholipid syndrome
  • Hughes syndrome

Prevalence: -

Inheritance: -

Age of onset:

ICD-10: D68.6

ICD-11: 4A45

UMLS: C0085278

MeSH: D016736

GARD: 5824

MedDRA: 10002817

A summary on this disease is available in Español (2023) Nederlands (2023)
Detailed information
General public
Article for general public
Clinical practice guidelines
English (2017) - Ann Rheum Dis Logo ERN
English (2019) - Ann Rheum Dis Logo ERN
Español (2020.pdf) - Asoc Española de Pediatría

Logo ERN: produced/endorsed by ERN(s) Logo FSMR: produced/endorsed by FSMR(s)

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